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Gene: CTXN1 |
Gene summary for CTXN1 |
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Gene information | Species | Human | Gene symbol | CTXN1 | Gene ID | 404217 |
Gene name | cortexin 1 | |
Gene Alias | CTXN | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P60606 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
404217 | CTXN1 | male-WTA | Human | Thyroid | PTC | 3.07e-41 | 5.36e-01 | 0.1037 |
404217 | CTXN1 | PTC01 | Human | Thyroid | PTC | 2.71e-09 | 2.38e-01 | 0.1899 |
404217 | CTXN1 | PTC04 | Human | Thyroid | PTC | 1.25e-05 | 1.61e-01 | 0.1927 |
404217 | CTXN1 | PTC05 | Human | Thyroid | PTC | 2.15e-15 | 5.53e-01 | 0.2065 |
404217 | CTXN1 | PTC06 | Human | Thyroid | PTC | 2.00e-32 | 6.81e-01 | 0.2057 |
404217 | CTXN1 | PTC07 | Human | Thyroid | PTC | 2.53e-27 | 4.94e-01 | 0.2044 |
404217 | CTXN1 | ATC09 | Human | Thyroid | ATC | 1.12e-05 | 2.29e-01 | 0.2871 |
404217 | CTXN1 | ATC13 | Human | Thyroid | ATC | 7.40e-31 | 6.75e-01 | 0.34 |
404217 | CTXN1 | ATC1 | Human | Thyroid | ATC | 8.73e-06 | 2.51e-01 | 0.2878 |
404217 | CTXN1 | ATC5 | Human | Thyroid | ATC | 8.04e-38 | 7.25e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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