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Gene: CD302 |
Gene summary for CD302 |
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Gene information | Species | Human | Gene symbol | CD302 | Gene ID | 9936 |
Gene name | CD302 molecule | |
Gene Alias | BIMLEC | |
Cytomap | 2q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8IX05 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9936 | CD302 | P2T-E | Human | Esophagus | ESCC | 7.59e-17 | 2.24e-01 | 0.1177 |
9936 | CD302 | P4T-E | Human | Esophagus | ESCC | 7.06e-04 | 6.55e-02 | 0.1323 |
9936 | CD302 | P8T-E | Human | Esophagus | ESCC | 1.20e-06 | 1.86e-01 | 0.0889 |
9936 | CD302 | P9T-E | Human | Esophagus | ESCC | 2.46e-03 | 2.11e-01 | 0.1131 |
9936 | CD302 | P10T-E | Human | Esophagus | ESCC | 1.79e-07 | 6.80e-02 | 0.116 |
9936 | CD302 | P12T-E | Human | Esophagus | ESCC | 1.26e-17 | 3.06e-01 | 0.1122 |
9936 | CD302 | P15T-E | Human | Esophagus | ESCC | 8.73e-19 | 4.59e-01 | 0.1149 |
9936 | CD302 | P16T-E | Human | Esophagus | ESCC | 2.30e-29 | 5.43e-01 | 0.1153 |
9936 | CD302 | P20T-E | Human | Esophagus | ESCC | 1.71e-06 | 7.37e-02 | 0.1124 |
9936 | CD302 | P22T-E | Human | Esophagus | ESCC | 2.44e-18 | 2.16e-01 | 0.1236 |
9936 | CD302 | P24T-E | Human | Esophagus | ESCC | 2.93e-02 | -2.63e-02 | 0.1287 |
9936 | CD302 | P26T-E | Human | Esophagus | ESCC | 4.69e-02 | -3.48e-02 | 0.1276 |
9936 | CD302 | P31T-E | Human | Esophagus | ESCC | 1.69e-04 | 4.32e-02 | 0.1251 |
9936 | CD302 | P32T-E | Human | Esophagus | ESCC | 1.77e-04 | 6.41e-02 | 0.1666 |
9936 | CD302 | P37T-E | Human | Esophagus | ESCC | 1.26e-06 | 6.66e-02 | 0.1371 |
9936 | CD302 | P42T-E | Human | Esophagus | ESCC | 2.30e-09 | 1.45e-01 | 0.1175 |
9936 | CD302 | P48T-E | Human | Esophagus | ESCC | 1.84e-06 | 1.52e-02 | 0.0959 |
9936 | CD302 | P56T-E | Human | Esophagus | ESCC | 1.94e-09 | 1.36e+00 | 0.1613 |
9936 | CD302 | P57T-E | Human | Esophagus | ESCC | 6.73e-10 | 1.06e-01 | 0.0926 |
9936 | CD302 | P61T-E | Human | Esophagus | ESCC | 5.10e-04 | 7.50e-02 | 0.099 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD302 | SNV | Missense_Mutation | c.335T>G | p.Phe112Cys | p.F112C | Q8IX05 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
CD302 | SNV | Missense_Mutation | c.637N>C | p.Tyr213His | p.Y213H | Q8IX05 | protein_coding | tolerated(0.07) | possibly_damaging(0.664) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD302 | SNV | Missense_Mutation | c.482N>T | p.Arg161Met | p.R161M | Q8IX05 | protein_coding | deleterious(0) | benign(0.332) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CD302 | SNV | Missense_Mutation | novel | c.243N>T | p.Lys81Asn | p.K81N | Q8IX05 | protein_coding | tolerated(0.16) | possibly_damaging(0.681) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD302 | SNV | Missense_Mutation | rs766645940 | c.182N>T | p.Ala61Val | p.A61V | Q8IX05 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CD302 | SNV | Missense_Mutation | c.189N>T | p.Met63Ile | p.M63I | Q8IX05 | protein_coding | tolerated(0.44) | benign(0.021) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD302 | SNV | Missense_Mutation | novel | c.459C>G | p.Cys153Trp | p.C153W | Q8IX05 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD302 | SNV | Missense_Mutation | novel | c.459C>G | p.Cys153Trp | p.C153W | Q8IX05 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EY-A1GR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CD302 | SNV | Missense_Mutation | novel | c.539N>C | p.Val180Ala | p.V180A | Q8IX05 | protein_coding | deleterious(0) | benign(0.323) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD302 | SNV | Missense_Mutation | novel | c.67G>T | p.Asp23Tyr | p.D23Y | Q8IX05 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-DD-AADC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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