Tissue | Expression Dynamics | Abbreviation |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:003051819 | Esophagus | ESCC | intracellular steroid hormone receptor signaling pathway | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:004340119 | Esophagus | ESCC | steroid hormone mediated signaling pathway | 87/8552 | 136/18723 | 1.25e-05 | 1.15e-04 | 87 |
GO:00165718 | Esophagus | ESCC | histone methylation | 89/8552 | 141/18723 | 2.17e-05 | 1.87e-04 | 89 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00456007 | Esophagus | ESCC | positive regulation of fat cell differentiation | 46/8552 | 66/18723 | 6.72e-05 | 5.11e-04 | 46 |
GO:19052142 | Esophagus | ESCC | regulation of RNA binding | 12/8552 | 12/18723 | 8.21e-05 | 6.01e-04 | 12 |
GO:00331438 | Esophagus | ESCC | regulation of intracellular steroid hormone receptor signaling pathway | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:000975516 | Esophagus | ESCC | hormone-mediated signaling pathway | 106/8552 | 190/18723 | 3.13e-03 | 1.30e-02 | 106 |
GO:003052014 | Esophagus | ESCC | intracellular estrogen receptor signaling pathway | 35/8552 | 54/18723 | 3.55e-03 | 1.45e-02 | 35 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CARM1 | SNV | Missense_Mutation | novel | c.687C>A | p.Asn229Lys | p.N229K | Q86X55 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A8-A08S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
CARM1 | SNV | Missense_Mutation | | c.608N>T | p.Ala203Val | p.A203V | Q86X55 | protein_coding | tolerated(0.74) | benign(0.111) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CARM1 | SNV | Missense_Mutation | | c.1560N>C | p.Leu520Phe | p.L520F | Q86X55 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.991) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CARM1 | SNV | Missense_Mutation | | c.950N>T | p.Ser317Phe | p.S317F | Q86X55 | protein_coding | deleterious(0.02) | probably_damaging(0.969) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
CARM1 | insertion | Nonsense_Mutation | novel | c.377_378insACAGGCATAAGCCACCGTGCCCGGCTTATTATTTCTTGTAGAGA | p.Cys127GlnfsTer3 | p.C127Qfs*3 | Q86X55 | protein_coding | | | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CARM1 | SNV | Missense_Mutation | novel | c.1255N>T | p.Arg419Trp | p.R419W | Q86X55 | protein_coding | deleterious(0.01) | possibly_damaging(0.771) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CARM1 | SNV | Missense_Mutation | | c.330N>C | p.Gln110His | p.Q110H | Q86X55 | protein_coding | tolerated(0.09) | benign(0.106) | TCGA-JW-A5VI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | topotecan | PD |
CARM1 | SNV | Missense_Mutation | rs765573504 | c.1204N>A | p.Val402Met | p.V402M | Q86X55 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CARM1 | SNV | Missense_Mutation | | c.1430C>T | p.Thr477Met | p.T477M | Q86X55 | protein_coding | deleterious(0.01) | possibly_damaging(0.814) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CARM1 | SNV | Missense_Mutation | | c.1134N>T | p.Met378Ile | p.M378I | Q86X55 | protein_coding | tolerated(0.35) | benign(0.035) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 336446915 | | |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | | EOSIN | EOSIN | 18348515 |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 178103610 | | |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 310264736 | | |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 315661334 | | |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 178103609 | | |
10498 | CARM1 | ENZYME, METHYL TRANSFERASE, DRUGGABLE GENOME | inhibitor | 315661333 | BIIB021 | |