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Gene: C4orf27 |
Gene summary for C4ORF27 |
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Gene information | Species | Human | Gene symbol | C4orf27 | Gene ID | 54969 |
Gene name | histone PARylation factor 1 | |
Gene Alias | C4orf27 | |
Cytomap | 4q33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NWY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54969 | C4orf27 | P1T-E | Human | Esophagus | ESCC | 1.23e-18 | 6.14e-01 | 0.0875 |
54969 | C4orf27 | P2T-E | Human | Esophagus | ESCC | 6.89e-44 | 7.97e-01 | 0.1177 |
54969 | C4orf27 | P4T-E | Human | Esophagus | ESCC | 2.42e-38 | 7.05e-01 | 0.1323 |
54969 | C4orf27 | P5T-E | Human | Esophagus | ESCC | 5.30e-21 | 3.68e-01 | 0.1327 |
54969 | C4orf27 | P8T-E | Human | Esophagus | ESCC | 7.52e-23 | 3.84e-01 | 0.0889 |
54969 | C4orf27 | P9T-E | Human | Esophagus | ESCC | 1.37e-15 | 3.62e-01 | 0.1131 |
54969 | C4orf27 | P10T-E | Human | Esophagus | ESCC | 7.28e-26 | 4.43e-01 | 0.116 |
54969 | C4orf27 | P11T-E | Human | Esophagus | ESCC | 6.73e-20 | 6.95e-01 | 0.1426 |
54969 | C4orf27 | P12T-E | Human | Esophagus | ESCC | 5.22e-43 | 7.33e-01 | 0.1122 |
54969 | C4orf27 | P15T-E | Human | Esophagus | ESCC | 1.55e-17 | 3.41e-01 | 0.1149 |
54969 | C4orf27 | P16T-E | Human | Esophagus | ESCC | 5.57e-40 | 6.24e-01 | 0.1153 |
54969 | C4orf27 | P17T-E | Human | Esophagus | ESCC | 5.71e-11 | 4.15e-01 | 0.1278 |
54969 | C4orf27 | P19T-E | Human | Esophagus | ESCC | 2.24e-09 | 5.45e-01 | 0.1662 |
54969 | C4orf27 | P20T-E | Human | Esophagus | ESCC | 7.72e-14 | 2.68e-01 | 0.1124 |
54969 | C4orf27 | P21T-E | Human | Esophagus | ESCC | 1.49e-39 | 5.86e-01 | 0.1617 |
54969 | C4orf27 | P22T-E | Human | Esophagus | ESCC | 5.03e-37 | 5.93e-01 | 0.1236 |
54969 | C4orf27 | P23T-E | Human | Esophagus | ESCC | 1.96e-17 | 3.88e-01 | 0.108 |
54969 | C4orf27 | P24T-E | Human | Esophagus | ESCC | 7.52e-23 | 4.39e-01 | 0.1287 |
54969 | C4orf27 | P26T-E | Human | Esophagus | ESCC | 1.05e-38 | 6.09e-01 | 0.1276 |
54969 | C4orf27 | P27T-E | Human | Esophagus | ESCC | 8.73e-28 | 4.28e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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