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Gene: C21orf33 |
Gene summary for C21ORF33 |
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Gene information | Species | Human | Gene symbol | C21orf33 | Gene ID | 8209 |
Gene name | glutamine amidotransferase class 1 domain containing 3 | |
Gene Alias | C21orf33 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | F2Z2Q0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8209 | C21orf33 | P2T-E | Human | Esophagus | ESCC | 8.08e-19 | 3.06e-01 | 0.1177 |
8209 | C21orf33 | P4T-E | Human | Esophagus | ESCC | 2.51e-57 | 1.23e+00 | 0.1323 |
8209 | C21orf33 | P8T-E | Human | Esophagus | ESCC | 7.28e-26 | 4.23e-01 | 0.0889 |
8209 | C21orf33 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.62e-01 | 0.1426 |
8209 | C21orf33 | P15T-E | Human | Esophagus | ESCC | 6.53e-23 | 5.08e-01 | 0.1149 |
8209 | C21orf33 | P16T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.84e-01 | 0.1153 |
8209 | C21orf33 | P17T-E | Human | Esophagus | ESCC | 3.31e-19 | 5.47e-01 | 0.1278 |
8209 | C21orf33 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.14e-01 | 0.1662 |
8209 | C21orf33 | P20T-E | Human | Esophagus | ESCC | 6.15e-13 | 2.56e-01 | 0.1124 |
8209 | C21orf33 | P22T-E | Human | Esophagus | ESCC | 5.30e-21 | 3.93e-01 | 0.1236 |
8209 | C21orf33 | P31T-E | Human | Esophagus | ESCC | 5.65e-55 | 8.34e-01 | 0.1251 |
8209 | C21orf33 | P32T-E | Human | Esophagus | ESCC | 4.19e-25 | 4.33e-01 | 0.1666 |
8209 | C21orf33 | P36T-E | Human | Esophagus | ESCC | 3.22e-20 | 5.74e-01 | 0.1187 |
8209 | C21orf33 | P38T-E | Human | Esophagus | ESCC | 1.00e-03 | 1.76e-01 | 0.127 |
8209 | C21orf33 | P39T-E | Human | Esophagus | ESCC | 3.58e-28 | 5.51e-01 | 0.0894 |
8209 | C21orf33 | P40T-E | Human | Esophagus | ESCC | 2.85e-25 | 6.23e-01 | 0.109 |
8209 | C21orf33 | P44T-E | Human | Esophagus | ESCC | 2.31e-16 | 4.10e-01 | 0.1096 |
8209 | C21orf33 | P48T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.49e-01 | 0.0959 |
8209 | C21orf33 | P49T-E | Human | Esophagus | ESCC | 3.75e-07 | 5.98e-01 | 0.1768 |
8209 | C21orf33 | P57T-E | Human | Esophagus | ESCC | 3.58e-28 | 4.45e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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