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Gene: C19orf53 |
Gene summary for C19ORF53 |
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Gene information | Species | Human | Gene symbol | C19orf53 | Gene ID | 28974 |
Gene name | chromosome 19 open reading frame 53 | |
Gene Alias | HSPC023 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9UNZ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28974 | C19orf53 | GSM4909280 | Human | Breast | Precancer | 1.16e-03 | -4.89e-01 | 0.0305 |
28974 | C19orf53 | GSM4909282 | Human | Breast | IDC | 1.46e-24 | 5.03e-01 | -0.0288 |
28974 | C19orf53 | GSM4909285 | Human | Breast | IDC | 7.49e-43 | 6.36e-01 | 0.21 |
28974 | C19orf53 | GSM4909286 | Human | Breast | IDC | 2.52e-05 | -3.61e-02 | 0.1081 |
28974 | C19orf53 | GSM4909287 | Human | Breast | IDC | 6.49e-13 | 3.84e-01 | 0.2057 |
28974 | C19orf53 | GSM4909288 | Human | Breast | IDC | 8.52e-04 | -4.05e-01 | 0.0988 |
28974 | C19orf53 | GSM4909290 | Human | Breast | IDC | 7.20e-16 | 5.40e-01 | 0.2096 |
28974 | C19orf53 | GSM4909291 | Human | Breast | IDC | 7.48e-16 | 5.17e-01 | 0.1753 |
28974 | C19orf53 | GSM4909293 | Human | Breast | IDC | 2.34e-02 | 2.25e-01 | 0.1581 |
28974 | C19orf53 | GSM4909294 | Human | Breast | IDC | 8.08e-07 | -1.23e-01 | 0.2022 |
28974 | C19orf53 | GSM4909296 | Human | Breast | IDC | 1.20e-19 | 3.05e-02 | 0.1524 |
28974 | C19orf53 | GSM4909297 | Human | Breast | IDC | 1.24e-23 | -2.03e-01 | 0.1517 |
28974 | C19orf53 | GSM4909298 | Human | Breast | IDC | 7.18e-10 | 3.43e-01 | 0.1551 |
28974 | C19orf53 | GSM4909301 | Human | Breast | IDC | 2.91e-10 | 2.63e-01 | 0.1577 |
28974 | C19orf53 | GSM4909304 | Human | Breast | IDC | 7.25e-13 | 3.66e-01 | 0.1636 |
28974 | C19orf53 | GSM4909309 | Human | Breast | IDC | 2.64e-03 | -1.84e-01 | 0.0483 |
28974 | C19orf53 | GSM4909311 | Human | Breast | IDC | 5.86e-57 | -2.12e-01 | 0.1534 |
28974 | C19orf53 | GSM4909312 | Human | Breast | IDC | 2.73e-17 | -5.42e-02 | 0.1552 |
28974 | C19orf53 | GSM4909313 | Human | Breast | IDC | 4.94e-03 | -9.67e-02 | 0.0391 |
28974 | C19orf53 | GSM4909315 | Human | Breast | IDC | 6.07e-21 | 4.46e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C19orf53 | SNV | Missense_Mutation | c.206N>G | p.Ala69Gly | p.A69G | Q9UNZ5 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A2-A0SU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
C19orf53 | SNV | Missense_Mutation | novel | c.201G>A | p.Met67Ile | p.M67I | Q9UNZ5 | protein_coding | tolerated(0.11) | benign(0.012) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
C19orf53 | SNV | Missense_Mutation | c.250G>A | p.Ala84Thr | p.A84T | Q9UNZ5 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C19orf53 | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q9UNZ5 | protein_coding | tolerated(0.14) | probably_damaging(0.999) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
C19orf53 | SNV | Missense_Mutation | rs746221045 | c.122C>T | p.Ala41Val | p.A41V | Q9UNZ5 | protein_coding | tolerated(0.1) | possibly_damaging(0.462) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C19orf53 | insertion | Frame_Shift_Ins | novel | c.33_34insA | p.Pro13ThrfsTer5 | p.P13Tfs*5 | Q9UNZ5 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C19orf53 | SNV | Missense_Mutation | c.49A>G | p.Lys17Glu | p.K17E | Q9UNZ5 | protein_coding | deleterious(0.01) | benign(0.399) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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