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Gene: C17orf58 |
Gene summary for C17ORF58 |
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Gene information | Species | Human | Gene symbol | C17orf58 | Gene ID | 284018 |
Gene name | chromosome 17 open reading frame 58 | |
Gene Alias | C17orf58 | |
Cytomap | 17q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q2M2W7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284018 | C17orf58 | GSM4909290 | Human | Breast | IDC | 8.21e-03 | 1.74e-01 | 0.2096 |
284018 | C17orf58 | GSM4909293 | Human | Breast | IDC | 2.69e-23 | 5.47e-01 | 0.1581 |
284018 | C17orf58 | GSM4909298 | Human | Breast | IDC | 2.64e-17 | 5.17e-01 | 0.1551 |
284018 | C17orf58 | GSM4909308 | Human | Breast | IDC | 2.47e-06 | 2.08e-01 | 0.158 |
284018 | C17orf58 | GSM4909311 | Human | Breast | IDC | 7.94e-04 | -1.90e-02 | 0.1534 |
284018 | C17orf58 | GSM4909319 | Human | Breast | IDC | 5.10e-08 | 3.70e-02 | 0.1563 |
284018 | C17orf58 | M1 | Human | Breast | IDC | 2.11e-09 | 3.09e-01 | 0.1577 |
284018 | C17orf58 | DCIS2 | Human | Breast | DCIS | 3.79e-08 | -1.29e-02 | 0.0085 |
284018 | C17orf58 | LZE4T | Human | Esophagus | ESCC | 4.45e-03 | 1.11e-01 | 0.0811 |
284018 | C17orf58 | LZE24T | Human | Esophagus | ESCC | 1.05e-16 | 5.52e-01 | 0.0596 |
284018 | C17orf58 | P2T-E | Human | Esophagus | ESCC | 5.69e-16 | 3.31e-01 | 0.1177 |
284018 | C17orf58 | P4T-E | Human | Esophagus | ESCC | 1.14e-07 | 2.32e-01 | 0.1323 |
284018 | C17orf58 | P5T-E | Human | Esophagus | ESCC | 4.27e-28 | 5.14e-01 | 0.1327 |
284018 | C17orf58 | P8T-E | Human | Esophagus | ESCC | 7.81e-35 | 6.92e-01 | 0.0889 |
284018 | C17orf58 | P9T-E | Human | Esophagus | ESCC | 1.14e-04 | 1.67e-01 | 0.1131 |
284018 | C17orf58 | P10T-E | Human | Esophagus | ESCC | 1.60e-19 | 2.65e-01 | 0.116 |
284018 | C17orf58 | P11T-E | Human | Esophagus | ESCC | 5.32e-10 | 4.12e-01 | 0.1426 |
284018 | C17orf58 | P12T-E | Human | Esophagus | ESCC | 2.32e-10 | 2.71e-01 | 0.1122 |
284018 | C17orf58 | P15T-E | Human | Esophagus | ESCC | 2.44e-15 | 3.55e-01 | 0.1149 |
284018 | C17orf58 | P16T-E | Human | Esophagus | ESCC | 6.22e-18 | 3.25e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C17orf58 | insertion | Frame_Shift_Ins | novel | c.7_8insAGAAGGG | p.Arg3GlnfsTer27 | p.R3Qfs*27 | Q2M2W7 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
C17orf58 | insertion | In_Frame_Ins | novel | c.5_6insACACCATTG | p.Asn2delinsLysHisHisCys | p.N2delinsKHHC | Q2M2W7 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
C17orf58 | SNV | Missense_Mutation | novel | c.122N>C | p.Met41Thr | p.M41T | Q2M2W7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.985) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
C17orf58 | SNV | Missense_Mutation | novel | c.131N>C | p.Ile44Thr | p.I44T | Q2M2W7 | protein_coding | deleterious_low_confidence(0.03) | benign(0.249) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C17orf58 | SNV | Missense_Mutation | c.209T>C | p.Leu70Pro | p.L70P | Q2M2W7 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-AD-6890-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C17orf58 | SNV | Missense_Mutation | rs542001619 | c.245N>A | p.Arg82Gln | p.R82Q | Q2M2W7 | protein_coding | deleterious(0.01) | possibly_damaging(0.853) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C17orf58 | SNV | Missense_Mutation | rs782365271 | c.185N>A | p.Arg62His | p.R62H | Q2M2W7 | protein_coding | tolerated_low_confidence(0.14) | benign(0.023) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
C17orf58 | SNV | Missense_Mutation | rs782074871 | c.236G>A | p.Arg79Lys | p.R79K | Q2M2W7 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C17orf58 | SNV | Missense_Mutation | novel | c.104G>T | p.Gly35Val | p.G35V | Q2M2W7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C17orf58 | SNV | Missense_Mutation | rs542001619 | c.245N>A | p.Arg82Gln | p.R82Q | Q2M2W7 | protein_coding | deleterious(0.01) | possibly_damaging(0.853) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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