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Gene: C16orf58 |
Gene summary for C16ORF58 |
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Gene information | Species | Human | Gene symbol | C16orf58 | Gene ID | 64755 |
Gene name | RUS family member 1 | |
Gene Alias | C16orf58 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024QZE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64755 | C16orf58 | LZE4T | Human | Esophagus | ESCC | 5.33e-03 | 6.08e-02 | 0.0811 |
64755 | C16orf58 | LZE7T | Human | Esophagus | ESCC | 3.16e-04 | 1.50e-01 | 0.0667 |
64755 | C16orf58 | LZE8T | Human | Esophagus | ESCC | 1.23e-04 | 9.74e-02 | 0.067 |
64755 | C16orf58 | LZE20T | Human | Esophagus | ESCC | 5.76e-07 | 1.27e-01 | 0.0662 |
64755 | C16orf58 | LZE22D1 | Human | Esophagus | HGIN | 1.10e-04 | 1.38e-01 | 0.0595 |
64755 | C16orf58 | LZE24T | Human | Esophagus | ESCC | 8.43e-15 | 3.86e-01 | 0.0596 |
64755 | C16orf58 | LZE21T | Human | Esophagus | ESCC | 9.04e-04 | 2.19e-01 | 0.0655 |
64755 | C16orf58 | P1T-E | Human | Esophagus | ESCC | 2.02e-12 | 3.83e-01 | 0.0875 |
64755 | C16orf58 | P2T-E | Human | Esophagus | ESCC | 3.93e-32 | 6.40e-01 | 0.1177 |
64755 | C16orf58 | P4T-E | Human | Esophagus | ESCC | 2.95e-11 | 1.86e-01 | 0.1323 |
64755 | C16orf58 | P5T-E | Human | Esophagus | ESCC | 5.62e-08 | 1.41e-01 | 0.1327 |
64755 | C16orf58 | P8T-E | Human | Esophagus | ESCC | 5.52e-20 | 2.14e-01 | 0.0889 |
64755 | C16orf58 | P9T-E | Human | Esophagus | ESCC | 8.23e-05 | 1.01e-01 | 0.1131 |
64755 | C16orf58 | P10T-E | Human | Esophagus | ESCC | 1.94e-20 | 2.61e-01 | 0.116 |
64755 | C16orf58 | P11T-E | Human | Esophagus | ESCC | 6.32e-13 | 3.97e-01 | 0.1426 |
64755 | C16orf58 | P12T-E | Human | Esophagus | ESCC | 5.66e-24 | 4.99e-01 | 0.1122 |
64755 | C16orf58 | P15T-E | Human | Esophagus | ESCC | 2.95e-20 | 3.24e-01 | 0.1149 |
64755 | C16orf58 | P16T-E | Human | Esophagus | ESCC | 3.37e-24 | 4.40e-01 | 0.1153 |
64755 | C16orf58 | P17T-E | Human | Esophagus | ESCC | 1.03e-08 | 3.34e-01 | 0.1278 |
64755 | C16orf58 | P19T-E | Human | Esophagus | ESCC | 7.06e-06 | 2.95e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf58 | insertion | Nonsense_Mutation | novel | c.318_319insATACCTTAAAGGCAGTTTTATACAGTATTT | p.Leu106_Ser107insIleProTerArgGlnPheTyrThrValPhe | p.L106_S107insIP*RQFYTVF | Q96GQ5 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C16orf58 | insertion | Frame_Shift_Ins | novel | c.1117_1118insTTCTTGGGCCTGGTGCAGAGGCTCACACCTAT | p.Ala373ValfsTer18 | p.A373Vfs*18 | Q96GQ5 | protein_coding | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
C16orf58 | SNV | Missense_Mutation | c.574N>T | p.Thr192Ser | p.T192S | Q96GQ5 | protein_coding | deleterious(0) | benign(0.334) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C16orf58 | SNV | Missense_Mutation | novel | c.799N>A | p.Leu267Ile | p.L267I | Q96GQ5 | protein_coding | deleterious(0.03) | possibly_damaging(0.491) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
C16orf58 | SNV | Missense_Mutation | novel | c.144N>A | p.Phe48Leu | p.F48L | Q96GQ5 | protein_coding | tolerated(0.13) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
C16orf58 | SNV | Missense_Mutation | c.1287N>T | p.Met429Ile | p.M429I | Q96GQ5 | protein_coding | deleterious(0.04) | benign(0) | TCGA-AY-4071-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C16orf58 | SNV | Missense_Mutation | c.548C>A | p.Pro183His | p.P183H | Q96GQ5 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C16orf58 | SNV | Missense_Mutation | novel | c.992N>C | p.Val331Ala | p.V331A | Q96GQ5 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
C16orf58 | SNV | Missense_Mutation | novel | c.436N>T | p.Arg146Cys | p.R146C | Q96GQ5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C16orf58 | SNV | Missense_Mutation | rs150175927 | c.1220N>A | p.Arg407Gln | p.R407Q | Q96GQ5 | protein_coding | tolerated(0.62) | benign(0) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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