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Gene: BTG1 |
Gene summary for BTG1 |
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Gene information | Species | Human | Gene symbol | BTG1 | Gene ID | 694 |
Gene name | BTG anti-proliferation factor 1 | |
Gene Alias | APRO2 | |
Cytomap | 12q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P62324 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
694 | BTG1 | GSM4909281 | Human | Breast | IDC | 1.61e-17 | -4.82e-01 | 0.21 |
694 | BTG1 | GSM4909282 | Human | Breast | IDC | 1.81e-13 | -4.73e-01 | -0.0288 |
694 | BTG1 | GSM4909285 | Human | Breast | IDC | 1.81e-08 | -2.11e-01 | 0.21 |
694 | BTG1 | GSM4909286 | Human | Breast | IDC | 5.07e-04 | 2.02e-01 | 0.1081 |
694 | BTG1 | GSM4909287 | Human | Breast | IDC | 2.11e-17 | -6.22e-01 | 0.2057 |
694 | BTG1 | GSM4909288 | Human | Breast | IDC | 3.85e-02 | -4.84e-01 | 0.0988 |
694 | BTG1 | GSM4909289 | Human | Breast | IDC | 9.80e-03 | -5.93e-01 | 0.1064 |
694 | BTG1 | GSM4909290 | Human | Breast | IDC | 3.97e-14 | -4.94e-01 | 0.2096 |
694 | BTG1 | GSM4909291 | Human | Breast | IDC | 6.95e-11 | -5.38e-01 | 0.1753 |
694 | BTG1 | GSM4909292 | Human | Breast | IDC | 4.07e-02 | -7.02e-01 | 0.1236 |
694 | BTG1 | GSM4909293 | Human | Breast | IDC | 1.30e-03 | -1.58e-01 | 0.1581 |
694 | BTG1 | GSM4909294 | Human | Breast | IDC | 2.06e-25 | -6.63e-01 | 0.2022 |
694 | BTG1 | GSM4909296 | Human | Breast | IDC | 7.63e-43 | -9.25e-01 | 0.1524 |
694 | BTG1 | GSM4909297 | Human | Breast | IDC | 1.24e-11 | -6.58e-02 | 0.1517 |
694 | BTG1 | GSM4909298 | Human | Breast | IDC | 4.21e-03 | -1.53e-01 | 0.1551 |
694 | BTG1 | GSM4909301 | Human | Breast | IDC | 1.53e-29 | -7.26e-01 | 0.1577 |
694 | BTG1 | GSM4909302 | Human | Breast | IDC | 5.21e-16 | -6.05e-01 | 0.1545 |
694 | BTG1 | GSM4909304 | Human | Breast | IDC | 1.04e-33 | -6.87e-01 | 0.1636 |
694 | BTG1 | GSM4909306 | Human | Breast | IDC | 1.68e-02 | -1.78e-01 | 0.1564 |
694 | BTG1 | GSM4909307 | Human | Breast | IDC | 1.55e-37 | -8.37e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:0045766 | Breast | Precancer | positive regulation of angiogenesis | 23/1080 | 181/18723 | 3.09e-04 | 4.43e-03 | 23 |
GO:1904018 | Breast | Precancer | positive regulation of vasculature development | 23/1080 | 181/18723 | 3.09e-04 | 4.43e-03 | 23 |
GO:00160497 | Breast | Precancer | cell growth | 46/1080 | 482/18723 | 5.63e-04 | 7.16e-03 | 46 |
GO:0045765 | Breast | Precancer | regulation of angiogenesis | 35/1080 | 342/18723 | 7.35e-04 | 8.80e-03 | 35 |
GO:1901342 | Breast | Precancer | regulation of vasculature development | 35/1080 | 348/18723 | 1.00e-03 | 1.12e-02 | 35 |
GO:00015587 | Breast | Precancer | regulation of cell growth | 39/1080 | 414/18723 | 1.81e-03 | 1.78e-02 | 39 |
GO:000697914 | Breast | IDC | response to oxidative stress | 83/1434 | 446/18723 | 2.36e-14 | 7.06e-12 | 83 |
GO:00434348 | Breast | IDC | response to peptide hormone | 54/1434 | 414/18723 | 8.25e-05 | 1.61e-03 | 54 |
GO:00457651 | Breast | IDC | regulation of angiogenesis | 45/1434 | 342/18723 | 2.57e-04 | 3.98e-03 | 45 |
GO:19013421 | Breast | IDC | regulation of vasculature development | 45/1434 | 348/18723 | 3.78e-04 | 5.38e-03 | 45 |
GO:001604913 | Breast | IDC | cell growth | 56/1434 | 482/18723 | 1.16e-03 | 1.26e-02 | 56 |
GO:00457661 | Breast | IDC | positive regulation of angiogenesis | 26/1434 | 181/18723 | 1.39e-03 | 1.43e-02 | 26 |
GO:19040181 | Breast | IDC | positive regulation of vasculature development | 26/1434 | 181/18723 | 1.39e-03 | 1.43e-02 | 26 |
GO:000155813 | Breast | IDC | regulation of cell growth | 49/1434 | 414/18723 | 1.55e-03 | 1.55e-02 | 49 |
GO:00073465 | Breast | IDC | regulation of mitotic cell cycle | 51/1434 | 457/18723 | 4.30e-03 | 3.35e-02 | 51 |
GO:000697924 | Breast | DCIS | response to oxidative stress | 82/1390 | 446/18723 | 1.22e-14 | 3.85e-12 | 82 |
GO:004343414 | Breast | DCIS | response to peptide hormone | 52/1390 | 414/18723 | 1.33e-04 | 2.28e-03 | 52 |
GO:00457652 | Breast | DCIS | regulation of angiogenesis | 44/1390 | 342/18723 | 2.50e-04 | 3.87e-03 | 44 |
GO:19013422 | Breast | DCIS | regulation of vasculature development | 44/1390 | 348/18723 | 3.67e-04 | 5.17e-03 | 44 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030186 | Breast | Precancer | RNA degradation | 14/684 | 79/8465 | 3.97e-03 | 2.37e-02 | 1.81e-02 | 14 |
hsa0301811 | Breast | Precancer | RNA degradation | 14/684 | 79/8465 | 3.97e-03 | 2.37e-02 | 1.81e-02 | 14 |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301861 | Oral cavity | NEOLP | RNA degradation | 18/1112 | 79/8465 | 1.25e-02 | 4.06e-02 | 2.56e-02 | 18 |
hsa0301871 | Oral cavity | NEOLP | RNA degradation | 18/1112 | 79/8465 | 1.25e-02 | 4.06e-02 | 2.56e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTG1 | SNV | Missense_Mutation | c.407N>G | p.Asn136Ser | p.N136S | P62324 | protein_coding | tolerated(0.57) | benign(0) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
BTG1 | SNV | Missense_Mutation | novel | c.128G>A | p.Ser43Asn | p.S43N | P62324 | protein_coding | tolerated(0.1) | benign(0.141) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTG1 | SNV | Missense_Mutation | novel | c.233N>T | p.Pro78Leu | p.P78L | P62324 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTG1 | SNV | Missense_Mutation | rs764941738 | c.415N>G | p.Asn139Asp | p.N139D | P62324 | protein_coding | tolerated(0.87) | benign(0.011) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
BTG1 | SNV | Missense_Mutation | novel | c.172N>G | p.Pro58Ala | p.P58A | P62324 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTG1 | SNV | Missense_Mutation | c.80N>C | p.Arg27Pro | p.R27P | P62324 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BTG1 | SNV | Missense_Mutation | c.365G>T | p.Cys122Phe | p.C122F | P62324 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CN-6021-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
BTG1 | insertion | Frame_Shift_Ins | novel | c.439_440insA | p.Ile147AsnfsTer4 | p.I147Nfs*4 | P62324 | protein_coding | TCGA-HC-8258-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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