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Gene: ATXN7L3B |
Gene summary for ATXN7L3B |
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Gene information | Species | Human | Gene symbol | ATXN7L3B | Gene ID | 552889 |
Gene name | ataxin 7 like 3B | |
Gene Alias | lnc-SCA7 | |
Cytomap | 12q21.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96GX2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
552889 | ATXN7L3B | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.81e-02 | 2.86e-01 | -0.0811 |
552889 | ATXN7L3B | HTA11_347_2000001011 | Human | Colorectum | AD | 7.30e-09 | 3.74e-01 | -0.1954 |
552889 | ATXN7L3B | HTA11_411_2000001011 | Human | Colorectum | SER | 2.95e-02 | 5.84e-01 | -0.2602 |
552889 | ATXN7L3B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.06e-05 | 3.63e-01 | -0.059 |
552889 | ATXN7L3B | HTA11_866_3004761011 | Human | Colorectum | AD | 9.15e-04 | 3.15e-01 | 0.096 |
552889 | ATXN7L3B | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.15e-02 | 4.80e-01 | 0.0131 |
552889 | ATXN7L3B | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.80e-04 | 3.32e-01 | -0.0177 |
552889 | ATXN7L3B | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.17e-08 | 6.32e-01 | 0.0171 |
552889 | ATXN7L3B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.00e-04 | 2.17e-01 | 0.0674 |
552889 | ATXN7L3B | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.18e-04 | 3.44e-01 | 0.0588 |
552889 | ATXN7L3B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.14e-11 | 4.44e-01 | 0.294 |
552889 | ATXN7L3B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.48e-12 | 5.66e-01 | 0.281 |
552889 | ATXN7L3B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.50e-11 | 4.85e-01 | 0.3859 |
552889 | ATXN7L3B | LZE2T | Human | Esophagus | ESCC | 1.40e-02 | 1.80e-01 | 0.082 |
552889 | ATXN7L3B | LZE4T | Human | Esophagus | ESCC | 1.87e-10 | 3.29e-01 | 0.0811 |
552889 | ATXN7L3B | LZE7T | Human | Esophagus | ESCC | 7.62e-05 | 3.78e-01 | 0.0667 |
552889 | ATXN7L3B | LZE8T | Human | Esophagus | ESCC | 3.09e-05 | 1.57e-01 | 0.067 |
552889 | ATXN7L3B | LZE20T | Human | Esophagus | ESCC | 7.88e-12 | 2.23e-01 | 0.0662 |
552889 | ATXN7L3B | LZE22T | Human | Esophagus | ESCC | 8.25e-04 | 9.38e-02 | 0.068 |
552889 | ATXN7L3B | LZE24T | Human | Esophagus | ESCC | 3.76e-15 | 5.00e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATXN7L3B | SNV | Missense_Mutation | novel | c.86N>A | p.Ser29Tyr | p.S29Y | Q96GX2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.557) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATXN7L3B | insertion | In_Frame_Ins | novel | c.266_267insCCA | p.Gln90dup | p.Q90dup | Q96GX2 | protein_coding | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | ||
ATXN7L3B | SNV | Missense_Mutation | novel | c.253N>T | p.Pro85Ser | p.P85S | Q96GX2 | protein_coding | tolerated_low_confidence(0.1) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATXN7L3B | SNV | Missense_Mutation | novel | c.115N>T | p.Arg39Trp | p.R39W | Q96GX2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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