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Gene: ATP6AP1 |
Gene summary for ATP6AP1 |
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Gene information | Species | Human | Gene symbol | ATP6AP1 | Gene ID | 537 |
Gene name | ATPase H+ transporting accessory protein 1 | |
Gene Alias | 16A | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q15904 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
537 | ATP6AP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.67e-17 | 3.90e-01 | 0.0155 |
537 | ATP6AP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.45e-18 | 7.14e-01 | -0.1808 |
537 | ATP6AP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.86e-23 | 8.20e-01 | -0.0811 |
537 | ATP6AP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.25e-21 | 6.73e-01 | -0.1088 |
537 | ATP6AP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.12e-38 | 8.12e-01 | -0.1954 |
537 | ATP6AP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.26e-14 | 1.19e+00 | -0.2602 |
537 | ATP6AP1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.10e-10 | 8.19e-01 | -0.2196 |
537 | ATP6AP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.61e-13 | 6.09e-01 | -0.1207 |
537 | ATP6AP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.11e-18 | 7.36e-01 | -0.1526 |
537 | ATP6AP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.47e-37 | 8.30e-01 | -0.1464 |
537 | ATP6AP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.94e-17 | 4.96e-01 | -0.1001 |
537 | ATP6AP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.57e-23 | 7.50e-01 | -0.059 |
537 | ATP6AP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.10e-11 | 8.33e-01 | -0.1706 |
537 | ATP6AP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.22e-11 | 8.16e-01 | -0.2061 |
537 | ATP6AP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.63e-04 | 5.45e-01 | -0.1462 |
537 | ATP6AP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.01e-08 | 6.31e-01 | -0.0842 |
537 | ATP6AP1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.46e-02 | 3.75e-01 | -0.00410000000000005 |
537 | ATP6AP1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.81e-05 | 5.22e-01 | -0.0179 |
537 | ATP6AP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.70e-25 | 6.74e-01 | 0.096 |
537 | ATP6AP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.07e-03 | 6.62e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902600 | Colorectum | AD | proton transmembrane transport | 66/3918 | 157/18723 | 1.59e-09 | 1.17e-07 | 66 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0046916 | Colorectum | AD | cellular transition metal ion homeostasis | 43/3918 | 115/18723 | 3.62e-05 | 6.56e-04 | 43 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0036295 | Colorectum | AD | cellular response to increased oxygen levels | 9/3918 | 14/18723 | 5.43e-04 | 5.79e-03 | 9 |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0071453 | Colorectum | AD | cellular response to oxygen levels | 55/3918 | 177/18723 | 9.48e-04 | 8.96e-03 | 55 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0006879 | Colorectum | AD | cellular iron ion homeostasis | 25/3918 | 67/18723 | 1.51e-03 | 1.27e-02 | 25 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa05110 | Colorectum | AD | Vibrio cholerae infection | 29/2092 | 50/8465 | 5.10e-07 | 7.12e-06 | 4.54e-06 | 29 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa051101 | Colorectum | AD | Vibrio cholerae infection | 29/2092 | 50/8465 | 5.10e-07 | 7.12e-06 | 4.54e-06 | 29 |
hsa001902 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa051102 | Colorectum | SER | Vibrio cholerae infection | 24/1580 | 50/8465 | 2.17e-06 | 3.13e-05 | 2.28e-05 | 24 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa001903 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa051103 | Colorectum | SER | Vibrio cholerae infection | 24/1580 | 50/8465 | 2.17e-06 | 3.13e-05 | 2.28e-05 | 24 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa001904 | Colorectum | MSS | Oxidative phosphorylation | 79/1875 | 134/8465 | 1.89e-20 | 7.90e-19 | 4.84e-19 | 79 |
hsa051104 | Colorectum | MSS | Vibrio cholerae infection | 27/1875 | 50/8465 | 8.58e-07 | 1.20e-05 | 7.34e-06 | 27 |
hsa05161 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa001905 | Colorectum | MSS | Oxidative phosphorylation | 79/1875 | 134/8465 | 1.89e-20 | 7.90e-19 | 4.84e-19 | 79 |
hsa051105 | Colorectum | MSS | Vibrio cholerae infection | 27/1875 | 50/8465 | 8.58e-07 | 1.20e-05 | 7.34e-06 | 27 |
hsa051611 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa051106 | Colorectum | MSI-H | Vibrio cholerae infection | 18/797 | 50/8465 | 2.77e-07 | 5.61e-06 | 4.70e-06 | 18 |
hsa04145 | Colorectum | MSI-H | Phagosome | 27/797 | 152/8465 | 8.74e-04 | 1.01e-02 | 8.48e-03 | 27 |
hsa051107 | Colorectum | MSI-H | Vibrio cholerae infection | 18/797 | 50/8465 | 2.77e-07 | 5.61e-06 | 4.70e-06 | 18 |
hsa041451 | Colorectum | MSI-H | Phagosome | 27/797 | 152/8465 | 8.74e-04 | 1.01e-02 | 8.48e-03 | 27 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP6AP1 | SNV | Missense_Mutation | c.256C>A | p.Pro86Thr | p.P86T | Q15904 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |
ATP6AP1 | SNV | Missense_Mutation | novel | c.697G>A | p.Val233Ile | p.V233I | Q15904 | protein_coding | tolerated(0.26) | benign(0.009) | TCGA-D8-A1XR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
ATP6AP1 | SNV | Missense_Mutation | rs781947223 | c.692N>A | p.Arg231His | p.R231H | Q15904 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ATP6AP1 | SNV | Missense_Mutation | c.107C>T | p.Ala36Val | p.A36V | Q15904 | protein_coding | tolerated(0.51) | benign(0) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
ATP6AP1 | SNV | Missense_Mutation | rs782516905 | c.406G>A | p.Val136Ile | p.V136I | Q15904 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ATP6AP1 | SNV | Missense_Mutation | rs782026906 | c.493N>T | p.Arg165Trp | p.R165W | Q15904 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP6AP1 | SNV | Missense_Mutation | novel | c.830N>T | p.Ala277Val | p.A277V | Q15904 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP6AP1 | SNV | Missense_Mutation | rs375162515 | c.988N>T | p.Arg330Cys | p.R330C | Q15904 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP6AP1 | SNV | Missense_Mutation | c.725N>A | p.Arg242His | p.R242H | Q15904 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP6AP1 | SNV | Missense_Mutation | c.184G>A | p.Asp62Asn | p.D62N | Q15904 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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