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Gene: ASCC1 |
Gene summary for ASCC1 |
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Gene information | Species | Human | Gene symbol | ASCC1 | Gene ID | 51008 |
Gene name | activating signal cointegrator 1 complex subunit 1 | |
Gene Alias | ASC1p50 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024QZM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51008 | ASCC1 | LZE4T | Human | Esophagus | ESCC | 1.34e-12 | 4.92e-01 | 0.0811 |
51008 | ASCC1 | LZE7T | Human | Esophagus | ESCC | 4.77e-02 | 1.77e-01 | 0.0667 |
51008 | ASCC1 | LZE24T | Human | Esophagus | ESCC | 2.00e-10 | 3.95e-01 | 0.0596 |
51008 | ASCC1 | LZE6T | Human | Esophagus | ESCC | 2.70e-11 | 4.36e-01 | 0.0845 |
51008 | ASCC1 | P1T-E | Human | Esophagus | ESCC | 8.42e-04 | 1.49e-01 | 0.0875 |
51008 | ASCC1 | P2T-E | Human | Esophagus | ESCC | 1.43e-21 | 3.96e-01 | 0.1177 |
51008 | ASCC1 | P4T-E | Human | Esophagus | ESCC | 1.25e-25 | 5.89e-01 | 0.1323 |
51008 | ASCC1 | P5T-E | Human | Esophagus | ESCC | 9.98e-19 | 3.70e-01 | 0.1327 |
51008 | ASCC1 | P8T-E | Human | Esophagus | ESCC | 1.42e-13 | 2.00e-01 | 0.0889 |
51008 | ASCC1 | P9T-E | Human | Esophagus | ESCC | 2.80e-11 | 1.98e-01 | 0.1131 |
51008 | ASCC1 | P10T-E | Human | Esophagus | ESCC | 4.15e-14 | 2.55e-01 | 0.116 |
51008 | ASCC1 | P11T-E | Human | Esophagus | ESCC | 3.04e-10 | 3.34e-01 | 0.1426 |
51008 | ASCC1 | P12T-E | Human | Esophagus | ESCC | 3.06e-19 | 4.38e-01 | 0.1122 |
51008 | ASCC1 | P15T-E | Human | Esophagus | ESCC | 3.96e-19 | 4.08e-01 | 0.1149 |
51008 | ASCC1 | P16T-E | Human | Esophagus | ESCC | 1.53e-31 | 4.87e-01 | 0.1153 |
51008 | ASCC1 | P17T-E | Human | Esophagus | ESCC | 2.39e-03 | 1.83e-01 | 0.1278 |
51008 | ASCC1 | P20T-E | Human | Esophagus | ESCC | 7.18e-21 | 3.09e-01 | 0.1124 |
51008 | ASCC1 | P21T-E | Human | Esophagus | ESCC | 1.89e-28 | 6.06e-01 | 0.1617 |
51008 | ASCC1 | P22T-E | Human | Esophagus | ESCC | 1.14e-12 | 2.59e-01 | 0.1236 |
51008 | ASCC1 | P23T-E | Human | Esophagus | ESCC | 8.71e-14 | 3.40e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASCC1 | SNV | Missense_Mutation | c.779N>A | p.Gly260Asp | p.G260D | Q8N9N2 | protein_coding | tolerated(0.09) | possibly_damaging(0.678) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ASCC1 | SNV | Missense_Mutation | novel | c.363N>A | p.Ser121Arg | p.S121R | Q8N9N2 | protein_coding | tolerated(0.37) | possibly_damaging(0.678) | TCGA-D8-A73W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
ASCC1 | SNV | Missense_Mutation | c.619N>T | p.His207Tyr | p.H207Y | Q8N9N2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
ASCC1 | SNV | Missense_Mutation | c.619N>T | p.His207Tyr | p.H207Y | Q8N9N2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ASCC1 | SNV | Missense_Mutation | novel | c.652N>A | p.Glu218Lys | p.E218K | Q8N9N2 | protein_coding | tolerated(0.08) | possibly_damaging(0.675) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ASCC1 | SNV | Missense_Mutation | c.991N>G | p.Lys331Glu | p.K331E | Q8N9N2 | protein_coding | tolerated(0.08) | possibly_damaging(0.718) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ASCC1 | SNV | Missense_Mutation | rs751027189 | c.14G>A | p.Arg5His | p.R5H | Q8N9N2 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
ASCC1 | SNV | Missense_Mutation | novel | c.880N>A | p.Leu294Ile | p.L294I | Q8N9N2 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ASCC1 | SNV | Missense_Mutation | rs779932786 | c.434N>A | p.Arg145Gln | p.R145Q | Q8N9N2 | protein_coding | deleterious(0.03) | possibly_damaging(0.866) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ASCC1 | SNV | Missense_Mutation | novel | c.1005G>T | p.Lys335Asn | p.K335N | Q8N9N2 | protein_coding | deleterious(0.03) | benign(0.178) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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