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Gene: ADAMTSL1 |
Gene summary for ADAMTSL1 |
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Gene information | Species | Human | Gene symbol | ADAMTSL1 | Gene ID | 92949 |
Gene name | ADAMTS like 1 | |
Gene Alias | ADAMTSL-1 | |
Cytomap | 9p22.2-p22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6MZQ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92949 | ADAMTSL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.73e-38 | -9.48e-01 | 0.0155 |
92949 | ADAMTSL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.54e-07 | -5.04e-01 | -0.1808 |
92949 | ADAMTSL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.41e-14 | -9.90e-01 | 0.0216 |
92949 | ADAMTSL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.41e-03 | -5.83e-01 | -0.0811 |
92949 | ADAMTSL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.05e-06 | -2.93e-01 | -0.1088 |
92949 | ADAMTSL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.05e-37 | 1.70e+00 | -0.1954 |
92949 | ADAMTSL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.90e-16 | 1.70e-01 | -0.2602 |
92949 | ADAMTSL1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.07e-12 | -1.16e+00 | -0.2196 |
92949 | ADAMTSL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.35e-06 | -6.08e-01 | -0.1207 |
92949 | ADAMTSL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.29e-14 | 8.46e-01 | -0.1526 |
92949 | ADAMTSL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.35e-08 | -7.90e-03 | -0.1464 |
92949 | ADAMTSL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.45e-14 | 4.76e-01 | -0.1001 |
92949 | ADAMTSL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.85e-17 | -7.98e-01 | -0.059 |
92949 | ADAMTSL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.46e-07 | 1.07e-01 | -0.1706 |
92949 | ADAMTSL1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.82e-03 | 3.80e-01 | -0.1462 |
92949 | ADAMTSL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.78e-03 | 2.39e-01 | -0.0842 |
92949 | ADAMTSL1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-18 | 9.91e-01 | -0.0179 |
92949 | ADAMTSL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.48e-16 | -7.55e-01 | 0.096 |
92949 | ADAMTSL1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.12e-03 | -6.72e-01 | 0.0446 |
92949 | ADAMTSL1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.45e-10 | -1.14e+00 | 0.0451 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTSL1 | SNV | Missense_Mutation | c.3900G>C | p.Gln1300His | p.Q1300H | Q8N6G6 | protein_coding | tolerated(0.16) | possibly_damaging(0.478) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
ADAMTSL1 | SNV | Missense_Mutation | c.5147N>C | p.Asn1716Thr | p.N1716T | Q8N6G6 | protein_coding | tolerated(1) | benign(0.068) | TCGA-A8-A075-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | CR | |
ADAMTSL1 | SNV | Missense_Mutation | c.4427G>T | p.Gly1476Val | p.G1476V | Q8N6G6 | protein_coding | tolerated(0.27) | probably_damaging(0.925) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADAMTSL1 | SNV | Missense_Mutation | c.4448N>A | p.Ser1483Tyr | p.S1483Y | Q8N6G6 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
ADAMTSL1 | SNV | Missense_Mutation | novel | c.1765G>A | p.Glu589Lys | p.E589K | Q8N6G6 | protein_coding | tolerated(0.42) | benign(0.2) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
ADAMTSL1 | SNV | Missense_Mutation | c.2644G>A | p.Val882Met | p.V882M | Q8N6G6 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ADAMTSL1 | SNV | Missense_Mutation | rs758189062 | c.4196N>T | p.Thr1399Met | p.T1399M | Q8N6G6 | protein_coding | tolerated(0.14) | benign(0.054) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ADAMTSL1 | SNV | Missense_Mutation | rs183926817 | c.4958N>T | p.Pro1653Leu | p.P1653L | Q8N6G6 | protein_coding | deleterious(0.04) | benign(0.129) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | c.4390N>G | p.Gln1464Glu | p.Q1464E | Q8N6G6 | protein_coding | tolerated(1) | benign(0.025) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
ADAMTSL1 | SNV | Missense_Mutation | c.4147A>T | p.Ile1383Phe | p.I1383F | Q8N6G6 | protein_coding | tolerated(0.74) | benign(0.036) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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