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Gene: ACTL8 |
Gene summary for ACTL8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ACTL8 | Gene ID | 81569 |
Gene name | actin like 8 | |
Gene Alias | CT57 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H568 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81569 | ACTL8 | HCC2 | Human | Liver | HCC | 4.15e-09 | 2.35e+00 | 0.5341 |
81569 | ACTL8 | S014 | Human | Liver | HCC | 1.15e-08 | 3.49e-01 | 0.2254 |
81569 | ACTL8 | S016 | Human | Liver | HCC | 2.68e-06 | 6.35e-01 | 0.2243 |
81569 | ACTL8 | S027 | Human | Liver | HCC | 7.07e-27 | 1.89e+00 | 0.2446 |
81569 | ACTL8 | S028 | Human | Liver | HCC | 4.22e-56 | 2.15e+00 | 0.2503 |
81569 | ACTL8 | S029 | Human | Liver | HCC | 8.04e-54 | 2.28e+00 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | |
Skin | AK | |
Skin | SCCIS | |
Skin | cSCC | |
Thyroid | HT |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTL8 | SNV | Missense_Mutation | c.241N>A | p.Leu81Ile | p.L81I | Q9H568 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACTL8 | SNV | Missense_Mutation | c.491N>A | p.Arg164His | p.R164H | Q9H568 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-AA-3870-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
ACTL8 | SNV | Missense_Mutation | c.166N>T | p.Asp56Tyr | p.D56Y | Q9H568 | protein_coding | deleterious(0.01) | benign(0.224) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACTL8 | SNV | Missense_Mutation | rs372742900 | c.469N>A | p.Val157Met | p.V157M | Q9H568 | protein_coding | tolerated(0.06) | benign(0.176) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACTL8 | SNV | Missense_Mutation | rs201038955 | c.212G>A | p.Arg71His | p.R71H | Q9H568 | protein_coding | deleterious(0.04) | benign(0.076) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACTL8 | SNV | Missense_Mutation | rs115824043 | c.332N>A | p.Arg111Gln | p.R111Q | Q9H568 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-F4-6808-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTL8 | SNV | Missense_Mutation | novel | c.160G>T | p.Gly54Cys | p.G54C | Q9H568 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTL8 | SNV | Missense_Mutation | c.727G>A | p.Gly243Ser | p.G243S | Q9H568 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
ACTL8 | SNV | Missense_Mutation | c.166N>A | p.Asp56Asn | p.D56N | Q9H568 | protein_coding | tolerated(0.19) | benign(0.02) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACTL8 | SNV | Missense_Mutation | novel | c.749N>A | p.Pro250His | p.P250H | Q9H568 | protein_coding | tolerated(0.09) | probably_damaging(0.969) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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