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Gene: ZNHIT2 |
Gene summary for ZNHIT2 |
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Gene information | Species | Human | Gene symbol | ZNHIT2 | Gene ID | 741 |
Gene name | zinc finger HIT-type containing 2 | |
Gene Alias | C11orf5 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9UHR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
741 | ZNHIT2 | LZE4T | Human | Esophagus | ESCC | 3.69e-07 | 1.51e-01 | 0.0811 |
741 | ZNHIT2 | LZE20T | Human | Esophagus | ESCC | 1.16e-04 | 1.55e-01 | 0.0662 |
741 | ZNHIT2 | LZE24T | Human | Esophagus | ESCC | 3.21e-05 | 3.11e-01 | 0.0596 |
741 | ZNHIT2 | P1T-E | Human | Esophagus | ESCC | 1.25e-06 | 2.64e-01 | 0.0875 |
741 | ZNHIT2 | P2T-E | Human | Esophagus | ESCC | 2.29e-14 | 2.31e-01 | 0.1177 |
741 | ZNHIT2 | P4T-E | Human | Esophagus | ESCC | 4.31e-18 | 5.34e-01 | 0.1323 |
741 | ZNHIT2 | P5T-E | Human | Esophagus | ESCC | 1.48e-18 | 2.89e-01 | 0.1327 |
741 | ZNHIT2 | P8T-E | Human | Esophagus | ESCC | 2.33e-07 | 1.30e-01 | 0.0889 |
741 | ZNHIT2 | P9T-E | Human | Esophagus | ESCC | 1.28e-13 | 2.89e-01 | 0.1131 |
741 | ZNHIT2 | P10T-E | Human | Esophagus | ESCC | 1.34e-14 | 3.52e-01 | 0.116 |
741 | ZNHIT2 | P11T-E | Human | Esophagus | ESCC | 3.00e-07 | 4.71e-01 | 0.1426 |
741 | ZNHIT2 | P12T-E | Human | Esophagus | ESCC | 1.30e-17 | 2.42e-01 | 0.1122 |
741 | ZNHIT2 | P15T-E | Human | Esophagus | ESCC | 1.85e-13 | 2.74e-01 | 0.1149 |
741 | ZNHIT2 | P16T-E | Human | Esophagus | ESCC | 2.14e-21 | 3.82e-01 | 0.1153 |
741 | ZNHIT2 | P17T-E | Human | Esophagus | ESCC | 5.72e-04 | 4.65e-01 | 0.1278 |
741 | ZNHIT2 | P20T-E | Human | Esophagus | ESCC | 3.13e-08 | 2.31e-01 | 0.1124 |
741 | ZNHIT2 | P21T-E | Human | Esophagus | ESCC | 1.53e-23 | 4.66e-01 | 0.1617 |
741 | ZNHIT2 | P22T-E | Human | Esophagus | ESCC | 2.24e-05 | 2.02e-01 | 0.1236 |
741 | ZNHIT2 | P23T-E | Human | Esophagus | ESCC | 8.39e-18 | 4.36e-01 | 0.108 |
741 | ZNHIT2 | P24T-E | Human | Esophagus | ESCC | 7.95e-15 | 3.12e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNHIT2 | deletion | Frame_Shift_Del | novel | c.737delG | p.Gly246AlafsTer114 | p.G246Afs*114 | Q9UHR6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNHIT2 | SNV | Missense_Mutation | c.619N>C | p.Val207Leu | p.V207L | Q9UHR6 | protein_coding | tolerated(0.16) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNHIT2 | SNV | Missense_Mutation | novel | c.1112N>C | p.Val371Ala | p.V371A | Q9UHR6 | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNHIT2 | SNV | Missense_Mutation | novel | c.1129G>A | p.Ala377Thr | p.A377T | Q9UHR6 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
ZNHIT2 | SNV | Missense_Mutation | novel | c.109N>G | p.Thr37Ala | p.T37A | Q9UHR6 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNHIT2 | SNV | Missense_Mutation | rs144753523 | c.1055N>T | p.Ala352Val | p.A352V | Q9UHR6 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNHIT2 | SNV | Missense_Mutation | novel | c.1156N>C | p.Trp386Arg | p.W386R | Q9UHR6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNHIT2 | SNV | Missense_Mutation | c.720C>G | p.Phe240Leu | p.F240L | Q9UHR6 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-BG-A0MI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNHIT2 | SNV | Missense_Mutation | novel | c.249N>C | p.Glu83Asp | p.E83D | Q9UHR6 | protein_coding | tolerated(0.66) | benign(0) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNHIT2 | SNV | Missense_Mutation | novel | c.125N>T | p.Ala42Val | p.A42V | Q9UHR6 | protein_coding | deleterious(0) | benign(0.046) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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