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Gene: ZNF575 |
Gene summary for ZNF575 |
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Gene information | Species | Human | Gene symbol | ZNF575 | Gene ID | 284346 |
Gene name | zinc finger protein 575 | |
Gene Alias | ZNF575 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0U0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284346 | ZNF575 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.73e-03 | 2.30e-01 | -0.1526 |
284346 | ZNF575 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.21e-06 | 2.70e-01 | -0.1464 |
284346 | ZNF575 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.91e-03 | 1.60e-01 | -0.059 |
284346 | ZNF575 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.17e-02 | 3.72e-01 | -0.1706 |
284346 | ZNF575 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.79e-02 | 3.93e-01 | -0.2061 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF575 | SNV | Missense_Mutation | c.65N>G | p.Pro22Arg | p.P22R | Q86XF7 | protein_coding | tolerated(0.31) | benign(0.018) | TCGA-C8-A26V-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | CR | |
ZNF575 | SNV | Missense_Mutation | rs745764744 | c.11N>A | p.Arg4Gln | p.R4Q | Q86XF7 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-LL-A5YL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZNF575 | SNV | Missense_Mutation | rs766918946 | c.34G>A | p.Ala12Thr | p.A12T | Q86XF7 | protein_coding | tolerated(0.5) | benign(0) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF575 | SNV | Missense_Mutation | rs756776103 | c.520N>A | p.Ala174Thr | p.A174T | Q86XF7 | protein_coding | tolerated(0.09) | possibly_damaging(0.738) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF575 | SNV | Missense_Mutation | novel | c.497N>A | p.Arg166His | p.R166H | Q86XF7 | protein_coding | deleterious(0.02) | benign(0.027) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF575 | SNV | Missense_Mutation | rs745764744 | c.11N>A | p.Arg4Gln | p.R4Q | Q86XF7 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF575 | SNV | Missense_Mutation | novel | c.323C>G | p.Ala108Gly | p.A108G | Q86XF7 | protein_coding | deleterious(0) | possibly_damaging(0.584) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF575 | SNV | Missense_Mutation | c.667G>T | p.Gly223Cys | p.G223C | Q86XF7 | protein_coding | deleterious(0.02) | possibly_damaging(0.905) | TCGA-22-5472-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
ZNF575 | SNV | Missense_Mutation | novel | c.182N>A | p.Arg61His | p.R61H | Q86XF7 | protein_coding | deleterious(0.01) | possibly_damaging(0.752) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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