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Gene: ZNF491 |
Gene summary for ZNF491 |
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Gene information | Species | Human | Gene symbol | ZNF491 | Gene ID | 126069 |
Gene name | zinc finger protein 491 | |
Gene Alias | ZNF491 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8N8L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126069 | ZNF491 | HCC1 | Human | Liver | HCC | 8.27e-05 | 4.46e-01 | 0.5336 |
126069 | ZNF491 | HCC2 | Human | Liver | HCC | 5.93e-12 | 8.85e-01 | 0.5341 |
126069 | ZNF491 | HCC5 | Human | Liver | HCC | 3.25e-10 | 6.16e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF491 | SNV | Missense_Mutation | c.965N>T | p.Thr322Ile | p.T322I | Q8N8L2 | protein_coding | deleterious(0.01) | possibly_damaging(0.857) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
ZNF491 | SNV | Missense_Mutation | rs199769397 | c.911G>A | p.Cys304Tyr | p.C304Y | Q8N8L2 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-D8-A142-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamid | SD |
ZNF491 | insertion | Frame_Shift_Ins | novel | c.245_246insTGAAGTGTCC | p.Lys82AsnfsTer9 | p.K82Nfs*9 | Q8N8L2 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF491 | SNV | Missense_Mutation | rs200317159 | c.692N>G | p.His231Arg | p.H231R | Q8N8L2 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF491 | SNV | Missense_Mutation | rs566438546 | c.1208N>T | p.Arg403Ile | p.R403I | Q8N8L2 | protein_coding | deleterious(0.02) | possibly_damaging(0.701) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF491 | SNV | Missense_Mutation | rs771073180 | c.238N>T | p.Arg80Cys | p.R80C | Q8N8L2 | protein_coding | tolerated(1) | benign(0) | TCGA-C5-A1MF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF491 | SNV | Missense_Mutation | novel | c.835G>A | p.Ala279Thr | p.A279T | Q8N8L2 | protein_coding | tolerated(0.17) | benign(0.149) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF491 | SNV | Missense_Mutation | rs376949228 | c.473N>A | p.Arg158Gln | p.R158Q | Q8N8L2 | protein_coding | deleterious(0.01) | benign(0) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
ZNF491 | SNV | Missense_Mutation | novel | c.1187N>C | p.Ile396Thr | p.I396T | Q8N8L2 | protein_coding | tolerated(0.14) | benign(0) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF491 | SNV | Missense_Mutation | rs376949228 | c.473G>A | p.Arg158Gln | p.R158Q | Q8N8L2 | protein_coding | deleterious(0.01) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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