![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF469 |
Gene summary for ZNF469 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF469 | Gene ID | 84627 |
Gene name | zinc finger protein 469 | |
Gene Alias | BCS | |
Cytomap | 16q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | H3BS19 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84627 | ZNF469 | ATC11 | Human | Thyroid | ATC | 1.60e-07 | 8.53e-01 | 0.3386 |
84627 | ZNF469 | ATC12 | Human | Thyroid | ATC | 5.95e-07 | 2.48e-01 | 0.34 |
84627 | ZNF469 | ATC13 | Human | Thyroid | ATC | 4.70e-13 | 2.63e-01 | 0.34 |
84627 | ZNF469 | ATC3 | Human | Thyroid | ATC | 2.42e-14 | 9.16e-01 | 0.338 |
84627 | ZNF469 | ATC4 | Human | Thyroid | ATC | 3.55e-10 | 3.16e-01 | 0.34 |
84627 | ZNF469 | ATC5 | Human | Thyroid | ATC | 2.12e-13 | 2.82e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF469 | SNV | Missense_Mutation | novel | c.3470G>A | p.Arg1157Lys | p.R1157K | Q96JG9 | protein_coding | tolerated(1) | benign(0.01) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZNF469 | SNV | Missense_Mutation | rs773010511 | c.11692N>A | p.Glu3898Lys | p.E3898K | Q96JG9 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ZNF469 | SNV | Missense_Mutation | rs557835484 | c.8261N>C | p.His2754Pro | p.H2754P | Q96JG9 | protein_coding | tolerated(0.08) | benign(0.225) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF469 | SNV | Missense_Mutation | novel | c.11308N>A | p.Glu3770Lys | p.E3770K | Q96JG9 | protein_coding | tolerated(0.08) | possibly_damaging(0.467) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF469 | SNV | Missense_Mutation | novel | c.4418T>G | p.Phe1473Cys | p.F1473C | Q96JG9 | protein_coding | tolerated(0.05) | benign(0.211) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF469 | SNV | Missense_Mutation | rs770164776 | c.11661N>C | p.Glu3887Asp | p.E3887D | Q96JG9 | protein_coding | deleterious(0.04) | benign(0.099) | TCGA-B6-A0RO-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF469 | SNV | Missense_Mutation | c.7766N>C | p.Arg2589Pro | p.R2589P | Q96JG9 | protein_coding | tolerated(0.07) | possibly_damaging(0.866) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF469 | SNV | Missense_Mutation | c.9171G>T | p.Gln3057His | p.Q3057H | Q96JG9 | protein_coding | deleterious(0) | benign(0.259) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF469 | SNV | Missense_Mutation | c.3601N>A | p.Glu1201Lys | p.E1201K | Q96JG9 | protein_coding | tolerated(0.14) | possibly_damaging(0.615) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF469 | SNV | Missense_Mutation | c.843N>A | p.His281Gln | p.H281Q | Q96JG9 | protein_coding | tolerated(0.07) | benign(0.067) | TCGA-BH-A204-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |