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Gene: ZNF394 |
Gene summary for ZNF394 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF394 | Gene ID | 84124 |
| Gene name | zinc finger protein 394 | |
| Gene Alias | ZKSCAN14 | |
| Cytomap | 7q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q53GI3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84124 | ZNF394 | LZE4T | Human | Esophagus | ESCC | 1.79e-09 | 1.98e-01 | 0.0811 |
| 84124 | ZNF394 | LZE7T | Human | Esophagus | ESCC | 3.60e-09 | 2.15e-01 | 0.0667 |
| 84124 | ZNF394 | LZE8T | Human | Esophagus | ESCC | 2.30e-10 | 2.47e-01 | 0.067 |
| 84124 | ZNF394 | LZE20T | Human | Esophagus | ESCC | 3.60e-07 | 9.92e-02 | 0.0662 |
| 84124 | ZNF394 | LZE24T | Human | Esophagus | ESCC | 1.24e-12 | 3.98e-01 | 0.0596 |
| 84124 | ZNF394 | LZE6T | Human | Esophagus | ESCC | 1.39e-05 | 1.62e-01 | 0.0845 |
| 84124 | ZNF394 | P1T-E | Human | Esophagus | ESCC | 2.80e-06 | 4.36e-01 | 0.0875 |
| 84124 | ZNF394 | P2T-E | Human | Esophagus | ESCC | 1.38e-25 | 4.52e-01 | 0.1177 |
| 84124 | ZNF394 | P4T-E | Human | Esophagus | ESCC | 1.58e-22 | 4.35e-01 | 0.1323 |
| 84124 | ZNF394 | P5T-E | Human | Esophagus | ESCC | 6.95e-18 | 2.73e-01 | 0.1327 |
| 84124 | ZNF394 | P8T-E | Human | Esophagus | ESCC | 5.29e-17 | 2.65e-01 | 0.0889 |
| 84124 | ZNF394 | P9T-E | Human | Esophagus | ESCC | 2.86e-13 | 3.49e-01 | 0.1131 |
| 84124 | ZNF394 | P10T-E | Human | Esophagus | ESCC | 2.39e-15 | 1.88e-01 | 0.116 |
| 84124 | ZNF394 | P11T-E | Human | Esophagus | ESCC | 6.98e-16 | 4.88e-01 | 0.1426 |
| 84124 | ZNF394 | P12T-E | Human | Esophagus | ESCC | 1.02e-29 | 4.41e-01 | 0.1122 |
| 84124 | ZNF394 | P15T-E | Human | Esophagus | ESCC | 1.12e-30 | 7.03e-01 | 0.1149 |
| 84124 | ZNF394 | P16T-E | Human | Esophagus | ESCC | 8.43e-37 | 7.28e-01 | 0.1153 |
| 84124 | ZNF394 | P17T-E | Human | Esophagus | ESCC | 3.93e-11 | 3.89e-01 | 0.1278 |
| 84124 | ZNF394 | P19T-E | Human | Esophagus | ESCC | 3.53e-02 | 2.26e-01 | 0.1662 |
| 84124 | ZNF394 | P20T-E | Human | Esophagus | ESCC | 4.53e-48 | 1.16e+00 | 0.1124 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Oral cavity | OSCC |  |
| Oral cavity | LP |  |
| Oral cavity | EOLP |  |
| Oral cavity | NEOLP |  |
| Esophagus | HGIN |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF394 | CT | Colorectum | ADJ | KLHL13,FAM155A,IDH3B, etc. | 4.74e-02 |  |
| ZNF394 | SSC | Colorectum | ADJ | KLHL13,FAM155A,IDH3B, etc. | 8.61e-03 | |
| ZNF394 | PERI | Oral cavity | LP | NAA35,PHACTR1,ADAMTS3, etc. | 1.26e-01 |  |
| ZNF394 | PERI | Oral cavity | OSCC | NAA35,PHACTR1,ADAMTS3, etc. | 1.18e-01 |  |
| ZNF394 | LYMEND | Skin | cSCC | NAP1L5,NAT14,PLPBP, etc. | 2.03e-01 |  |
| ZNF394 | PTC | Thyroid | Healthy | LIPA,MTERF4,RCHY1, etc. | 1.73e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF394 | SNV | Missense_Mutation | c.38N>G | p.Asp13Gly | p.D13G | Q53GI3 | protein_coding | tolerated_low_confidence(0.18) | benign(0.001) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
| ZNF394 | SNV | Missense_Mutation | novel | c.728N>G | p.Val243Gly | p.V243G | Q53GI3 | protein_coding | tolerated(0.11) | benign(0) | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR |
| ZNF394 | SNV | Missense_Mutation | novel | c.428N>G | p.Gln143Arg | p.Q143R | Q53GI3 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| ZNF394 | SNV | Missense_Mutation | novel | c.821G>T | p.Gly274Val | p.G274V | Q53GI3 | protein_coding | tolerated(0.55) | benign(0.005) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF394 | SNV | Missense_Mutation | novel | c.519C>A | p.Asp173Glu | p.D173E | Q53GI3 | protein_coding | tolerated(0.52) | benign(0.127) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ZNF394 | SNV | Missense_Mutation | c.206N>C | p.Gln69Pro | p.Q69P | Q53GI3 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF394 | SNV | Missense_Mutation | rs769653041 | c.1514G>A | p.Arg505His | p.R505H | Q53GI3 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| ZNF394 | SNV | Missense_Mutation | c.190N>G | p.Arg64Gly | p.R64G | Q53GI3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF394 | insertion | Nonsense_Mutation | novel | c.739_740insTTCAAACAACGCTCTGACCTCTTTAGACA | p.Ser247PhefsTer6 | p.S247Ffs*6 | Q53GI3 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ZNF394 | insertion | Nonsense_Mutation | novel | c.1108_1109insCAAAGAATTCATCAAAATAAAGT | p.Arg370ProfsTer7 | p.R370Pfs*7 | Q53GI3 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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