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Gene: ZNF24 |
Gene summary for ZNF24 |
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Gene information | Species | Human | Gene symbol | ZNF24 | Gene ID | 7572 |
Gene name | zinc finger protein 24 | |
Gene Alias | KOX17 | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17028 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7572 | ZNF24 | LZE4T | Human | Esophagus | ESCC | 1.95e-13 | 4.61e-01 | 0.0811 |
7572 | ZNF24 | LZE5T | Human | Esophagus | ESCC | 4.93e-06 | 3.24e-01 | 0.0514 |
7572 | ZNF24 | LZE7T | Human | Esophagus | ESCC | 5.15e-12 | 9.67e-01 | 0.0667 |
7572 | ZNF24 | LZE8T | Human | Esophagus | ESCC | 8.23e-11 | 1.36e-01 | 0.067 |
7572 | ZNF24 | LZE20T | Human | Esophagus | ESCC | 1.47e-11 | 1.99e-01 | 0.0662 |
7572 | ZNF24 | LZE22T | Human | Esophagus | ESCC | 5.51e-04 | 2.50e-01 | 0.068 |
7572 | ZNF24 | LZE24T | Human | Esophagus | ESCC | 2.47e-21 | 6.15e-01 | 0.0596 |
7572 | ZNF24 | LZE21T | Human | Esophagus | ESCC | 1.07e-03 | 1.75e-01 | 0.0655 |
7572 | ZNF24 | LZE6T | Human | Esophagus | ESCC | 3.11e-02 | 6.00e-02 | 0.0845 |
7572 | ZNF24 | P1T-E | Human | Esophagus | ESCC | 6.15e-07 | 5.98e-01 | 0.0875 |
7572 | ZNF24 | P2T-E | Human | Esophagus | ESCC | 1.43e-57 | 1.03e+00 | 0.1177 |
7572 | ZNF24 | P4T-E | Human | Esophagus | ESCC | 1.30e-42 | 9.14e-01 | 0.1323 |
7572 | ZNF24 | P5T-E | Human | Esophagus | ESCC | 1.61e-16 | 2.29e-01 | 0.1327 |
7572 | ZNF24 | P8T-E | Human | Esophagus | ESCC | 3.99e-38 | 6.54e-01 | 0.0889 |
7572 | ZNF24 | P9T-E | Human | Esophagus | ESCC | 3.15e-37 | 8.42e-01 | 0.1131 |
7572 | ZNF24 | P10T-E | Human | Esophagus | ESCC | 2.13e-34 | 6.40e-01 | 0.116 |
7572 | ZNF24 | P11T-E | Human | Esophagus | ESCC | 1.06e-30 | 8.26e-01 | 0.1426 |
7572 | ZNF24 | P12T-E | Human | Esophagus | ESCC | 1.01e-46 | 9.65e-01 | 0.1122 |
7572 | ZNF24 | P15T-E | Human | Esophagus | ESCC | 2.55e-31 | 6.92e-01 | 0.1149 |
7572 | ZNF24 | P16T-E | Human | Esophagus | ESCC | 2.34e-32 | 7.39e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
GO:00072722 | Oral cavity | NEOLP | ensheathment of neurons | 24/2005 | 136/18723 | 9.59e-03 | 4.53e-02 | 24 |
GO:00083662 | Oral cavity | NEOLP | axon ensheathment | 24/2005 | 136/18723 | 9.59e-03 | 4.53e-02 | 24 |
GO:00425522 | Prostate | Tumor | myelination | 34/3246 | 134/18723 | 1.19e-02 | 4.85e-02 | 34 |
GO:004255221 | Skin | cSCC | myelination | 51/4864 | 134/18723 | 1.37e-03 | 8.70e-03 | 51 |
GO:000727221 | Skin | cSCC | ensheathment of neurons | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:000836621 | Skin | cSCC | axon ensheathment | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:00425526 | Thyroid | ATC | myelination | 62/6293 | 134/18723 | 1.54e-03 | 7.84e-03 | 62 |
GO:00072726 | Thyroid | ATC | ensheathment of neurons | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF24 | SNV | Missense_Mutation | c.527T>G | p.Leu176Arg | p.L176R | P17028 | protein_coding | tolerated(0.06) | possibly_damaging(0.879) | TCGA-BH-A1FR-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF24 | insertion | Frame_Shift_Ins | novel | c.999_1000insGAAACAGAAAATGTAAATATCATTCATTATCTATTAAGGGAAAAAGAAA | p.Pro334GlufsTer19 | p.P334Efs*19 | P17028 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF24 | deletion | Frame_Shift_Del | novel | c.15delN | p.Val6TrpfsTer19 | p.V6Wfs*19 | P17028 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF24 | SNV | Missense_Mutation | rs757349943 | c.155G>A | p.Arg52Gln | p.R52Q | P17028 | protein_coding | deleterious(0) | benign(0.38) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF24 | SNV | Missense_Mutation | c.980N>T | p.Arg327Ile | p.R327I | P17028 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF24 | SNV | Missense_Mutation | c.841N>C | p.Cys281Arg | p.C281R | P17028 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF24 | SNV | Missense_Mutation | c.1048N>A | p.Leu350Ile | p.L350I | P17028 | protein_coding | deleterious(0.01) | possibly_damaging(0.722) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF24 | SNV | Missense_Mutation | rs781423777 | c.434N>A | p.Arg145Gln | p.R145Q | P17028 | protein_coding | tolerated(0.64) | benign(0.045) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF24 | SNV | Missense_Mutation | novel | c.354N>T | p.Glu118Asp | p.E118D | P17028 | protein_coding | tolerated(0.08) | possibly_damaging(0.458) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF24 | SNV | Missense_Mutation | c.959C>T | p.Ser320Leu | p.S320L | P17028 | protein_coding | deleterious(0) | possibly_damaging(0.456) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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