![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: WLS |
Gene summary for WLS |
![]() |
Gene information | Species | Human | Gene symbol | WLS | Gene ID | 79971 |
Gene name | Wnt ligand secretion mediator | |
Gene Alias | C1orf139 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q5T9L3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79971 | WLS | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.39e-13 | -5.05e-01 | 0.0155 |
79971 | WLS | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.91e-02 | -3.87e-01 | -0.1808 |
79971 | WLS | HTA11_347_2000001011 | Human | Colorectum | AD | 3.79e-03 | -1.09e-01 | -0.1954 |
79971 | WLS | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.37e-03 | -4.45e-01 | -0.1207 |
79971 | WLS | HTA11_696_2000001011 | Human | Colorectum | AD | 2.83e-05 | -4.16e-01 | -0.1464 |
79971 | WLS | HTA11_866_2000001011 | Human | Colorectum | AD | 1.44e-06 | -4.46e-01 | -0.1001 |
79971 | WLS | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.52e-03 | -3.77e-01 | -0.059 |
79971 | WLS | HTA11_546_2000001011 | Human | Colorectum | AD | 3.69e-02 | -4.67e-01 | -0.0842 |
79971 | WLS | HTA11_866_3004761011 | Human | Colorectum | AD | 6.67e-06 | -4.02e-01 | 0.096 |
79971 | WLS | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.46e-02 | -4.00e-01 | 0.0338 |
79971 | WLS | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.10e-09 | -4.22e-01 | 0.0674 |
79971 | WLS | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.58e-05 | -3.78e-01 | 0.294 |
79971 | WLS | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.73e-02 | -3.56e-01 | 0.281 |
79971 | WLS | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.55e-05 | -5.54e-01 | 0.2585 |
79971 | WLS | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.64e-04 | -3.97e-01 | 0.3005 |
79971 | WLS | F007 | Human | Colorectum | FAP | 3.62e-03 | -2.30e-01 | 0.1176 |
79971 | WLS | A001-C-207 | Human | Colorectum | FAP | 5.84e-06 | -3.41e-01 | 0.1278 |
79971 | WLS | A015-C-203 | Human | Colorectum | FAP | 3.28e-13 | -3.93e-01 | -0.1294 |
79971 | WLS | A015-C-204 | Human | Colorectum | FAP | 1.41e-04 | -2.82e-01 | -0.0228 |
79971 | WLS | A002-C-201 | Human | Colorectum | FAP | 7.41e-15 | -4.46e-01 | 0.0324 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0043123 | Colorectum | AD | positive regulation of I-kappaB kinase/NF-kappaB signaling | 60/3918 | 186/18723 | 1.91e-04 | 2.56e-03 | 60 |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0030901 | Colorectum | AD | midbrain development | 32/3918 | 90/18723 | 9.45e-04 | 8.95e-03 | 32 |
GO:0030177 | Colorectum | AD | positive regulation of Wnt signaling pathway | 45/3918 | 140/18723 | 1.23e-03 | 1.09e-02 | 45 |
GO:0050714 | Colorectum | AD | positive regulation of protein secretion | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WLS | SNV | Missense_Mutation | novel | c.1484A>C | p.Lys495Thr | p.K495T | Q5T9L3 | protein_coding | deleterious(0.03) | probably_damaging(0.921) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WLS | SNV | Missense_Mutation | c.473N>C | p.Leu158Pro | p.L158P | Q5T9L3 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
WLS | SNV | Missense_Mutation | c.466N>G | p.Arg156Gly | p.R156G | Q5T9L3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
WLS | SNV | Missense_Mutation | c.440C>T | p.Thr147Ile | p.T147I | Q5T9L3 | protein_coding | tolerated(0.07) | possibly_damaging(0.812) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | c.376N>C | p.Glu126Gln | p.E126Q | Q5T9L3 | protein_coding | tolerated(0.3) | benign(0.071) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | c.416N>A | p.Arg139His | p.R139H | Q5T9L3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-E2-A15D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
WLS | SNV | Missense_Mutation | c.1064N>A | p.Arg355Lys | p.R355K | Q5T9L3 | protein_coding | deleterious(0.05) | probably_damaging(0.972) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | rs368075278 | c.154N>T | p.Arg52Cys | p.R52C | Q5T9L3 | protein_coding | tolerated(0.05) | benign(0.34) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WLS | SNV | Missense_Mutation | c.449N>T | p.Ala150Val | p.A150V | Q5T9L3 | protein_coding | tolerated(0.1) | benign(0.225) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | c.152C>T | p.Ala51Val | p.A51V | Q5T9L3 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |