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Gene: WDR1 |
Gene summary for WDR1 |
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Gene information | Species | Human | Gene symbol | WDR1 | Gene ID | 9948 |
Gene name | WD repeat domain 1 | |
Gene Alias | AIP1 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75083 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9948 | WDR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.50e-12 | 7.03e-01 | -0.1808 |
9948 | WDR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.16e-12 | 7.43e-01 | -0.0811 |
9948 | WDR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.16e-09 | 5.47e-01 | -0.1088 |
9948 | WDR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.84e-26 | 7.52e-01 | -0.1954 |
9948 | WDR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.94e-10 | 1.37e+00 | -0.2602 |
9948 | WDR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.18e-05 | 8.15e-01 | -0.2196 |
9948 | WDR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.25e-02 | 4.03e-01 | -0.1207 |
9948 | WDR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.23e-05 | 6.57e-01 | -0.1526 |
9948 | WDR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.50e-17 | 6.21e-01 | -0.1464 |
9948 | WDR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.94e-05 | 2.52e-01 | -0.1001 |
9948 | WDR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.98e-15 | 8.14e-01 | -0.059 |
9948 | WDR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.65e-09 | 1.11e+00 | -0.1706 |
9948 | WDR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.39e-06 | 7.70e-01 | -0.2061 |
9948 | WDR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.04e-02 | 3.81e-01 | -0.0179 |
9948 | WDR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.23e-09 | 4.61e-01 | 0.096 |
9948 | WDR1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.16e-02 | 4.75e-01 | -0.0177 |
9948 | WDR1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.82e-05 | 8.33e-01 | 0.0171 |
9948 | WDR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.66e-10 | 4.19e-01 | 0.0674 |
9948 | WDR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.51e-15 | 4.73e-01 | 0.294 |
9948 | WDR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.57e-10 | 5.91e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0007043 | Colorectum | AD | cell-cell junction assembly | 57/3918 | 146/18723 | 4.18e-07 | 1.61e-05 | 57 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR1 | SNV | Missense_Mutation | novel | c.1043N>G | p.Tyr348Cys | p.Y348C | O75083 | protein_coding | tolerated(0.14) | possibly_damaging(0.807) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | novel | c.1041N>G | p.Asn347Lys | p.N347K | O75083 | protein_coding | tolerated(0.3) | possibly_damaging(0.739) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | c.1606N>C | p.Val536Leu | p.V536L | O75083 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WDR1 | deletion | Frame_Shift_Del | novel | c.748delN | p.Leu250PhefsTer16 | p.L250Ffs*16 | O75083 | protein_coding | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |||
WDR1 | SNV | Missense_Mutation | novel | c.532C>T | p.Pro178Ser | p.P178S | O75083 | protein_coding | deleterious(0) | benign(0.03) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs545497657 | c.700G>A | p.Asp234Asn | p.D234N | O75083 | protein_coding | tolerated(0.49) | benign(0.011) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs868174972 | c.200N>T | p.Ala67Val | p.A67V | O75083 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR1 | SNV | Missense_Mutation | novel | c.638N>C | p.Ile213Thr | p.I213T | O75083 | protein_coding | deleterious(0.01) | possibly_damaging(0.493) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
WDR1 | SNV | Missense_Mutation | c.1319N>A | p.Ser440Asn | p.S440N | O75083 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
WDR1 | SNV | Missense_Mutation | rs370326840 | c.1222G>A | p.Val408Ile | p.V408I | O75083 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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