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Gene: TYW1B |
Gene summary for TYW1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TYW1B | Gene ID | 441250 |
| Gene name | tRNA-yW synthesizing protein 1 homolog B | |
| Gene Alias | LINC00069 | |
| Cytomap | 7q11.22-q11.23 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087WZB2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 441250 | TYW1B | CCI_1 | Human | Cervix | CC | 9.97e-06 | 4.46e-01 | 0.528 |
| 441250 | TYW1B | CCI_2 | Human | Cervix | CC | 2.97e-13 | 1.11e+00 | 0.5249 |
| 441250 | TYW1B | CCI_3 | Human | Cervix | CC | 4.04e-10 | 6.07e-01 | 0.516 |
| 441250 | TYW1B | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.48e-03 | 4.72e-01 | 0.343 |
| 441250 | TYW1B | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.12e-03 | 3.97e-01 | 0.3329 |
| 441250 | TYW1B | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 8.87e-03 | 2.10e-01 | -0.2116 |
| 441250 | TYW1B | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 9.09e-03 | 3.44e-01 | -0.2107 |
| 441250 | TYW1B | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.98e-05 | 3.14e-01 | -0.2119 |
| 441250 | TYW1B | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.03e-03 | 3.42e-01 | 0.1829 |
| 441250 | TYW1B | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.67e-02 | 2.60e-01 | 0.1859 |
| 441250 | TYW1B | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.64e-16 | 5.13e-01 | -0.0166 |
| 441250 | TYW1B | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.68e-19 | 5.56e-01 | -0.0132 |
| 441250 | TYW1B | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 5.10e-22 | 5.96e-01 | -0.013 |
| 441250 | TYW1B | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 6.93e-13 | 4.42e-01 | -0.0121 |
| 441250 | TYW1B | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.37e-02 | 2.98e-01 | -0.0961 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Oral cavity | OSCC |  |
| Oral cavity | LP |  |
| Oral cavity | EOLP |  |
| Oral cavity | NEOLP |  |
| Esophagus | HGIN |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TYW1B | SNV | Missense_Mutation | novel | c.161N>T | p.Ala54Val | p.A54V | protein_coding | tolerated(0.25) | possibly_damaging(0.816) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
| TYW1B | SNV | Missense_Mutation | novel | c.239N>C | p.Val80Ala | p.V80A | protein_coding | tolerated(0.61) | benign(0.015) | TCGA-B6-A0WY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| TYW1B | SNV | Missense_Mutation | novel | c.1024N>G | p.Arg342Gly | p.R342G | protein_coding | deleterious(0) | benign(0.216) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TYW1B | SNV | Missense_Mutation | novel | c.1210N>A | p.Ala404Thr | p.A404T | protein_coding | tolerated(0.4) | benign(0.043) | TCGA-OL-A5RZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
| TYW1B | SNV | Missense_Mutation | novel | c.552N>T | p.Arg184Ser | p.R184S | protein_coding | tolerated(0.42) | benign(0.005) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TYW1B | insertion | In_Frame_Ins | novel | c.547_548insGCCTGTTGTCTCAGC | p.Phe183delinsCysLeuLeuSerGlnLeu | p.F183delinsCLLSQL | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | |||
| TYW1B | SNV | Missense_Mutation | novel | c.620G>A | p.Gly207Asp | p.G207D | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| TYW1B | SNV | Missense_Mutation | novel | c.1810A>T | p.Thr604Ser | p.T604S | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| TYW1B | SNV | Missense_Mutation | novel | c.1636N>A | p.Glu546Lys | p.E546K | protein_coding | tolerated(0.26) | benign(0.062) | TCGA-IR-A3LF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| TYW1B | SNV | Missense_Mutation | novel | c.1297N>G | p.Phe433Val | p.F433V | protein_coding | deleterious(0) | possibly_damaging(0.595) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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