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Gene: TRIB2 |
Gene summary for TRIB2 |
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Gene information | Species | Human | Gene symbol | TRIB2 | Gene ID | 28951 |
Gene name | tribbles pseudokinase 2 | |
Gene Alias | C5FW | |
Cytomap | 2p24.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q92519 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28951 | TRIB2 | LZE4T | Human | Esophagus | ESCC | 7.18e-03 | 1.66e-01 | 0.0811 |
28951 | TRIB2 | LZE7T | Human | Esophagus | ESCC | 4.42e-05 | 4.01e-01 | 0.0667 |
28951 | TRIB2 | LZE8T | Human | Esophagus | ESCC | 1.40e-05 | 2.71e-01 | 0.067 |
28951 | TRIB2 | LZE24T | Human | Esophagus | ESCC | 1.12e-02 | 2.32e-02 | 0.0596 |
28951 | TRIB2 | LZE21T | Human | Esophagus | ESCC | 5.54e-04 | 1.78e-01 | 0.0655 |
28951 | TRIB2 | P1T-E | Human | Esophagus | ESCC | 1.53e-03 | 2.02e-01 | 0.0875 |
28951 | TRIB2 | P2T-E | Human | Esophagus | ESCC | 1.82e-44 | 9.09e-01 | 0.1177 |
28951 | TRIB2 | P4T-E | Human | Esophagus | ESCC | 4.72e-04 | 9.41e-02 | 0.1323 |
28951 | TRIB2 | P5T-E | Human | Esophagus | ESCC | 1.82e-08 | 1.77e-02 | 0.1327 |
28951 | TRIB2 | P8T-E | Human | Esophagus | ESCC | 8.21e-19 | 3.32e-01 | 0.0889 |
28951 | TRIB2 | P9T-E | Human | Esophagus | ESCC | 1.62e-12 | 4.14e-01 | 0.1131 |
28951 | TRIB2 | P10T-E | Human | Esophagus | ESCC | 1.59e-21 | 4.40e-01 | 0.116 |
28951 | TRIB2 | P12T-E | Human | Esophagus | ESCC | 9.43e-10 | 2.09e-01 | 0.1122 |
28951 | TRIB2 | P15T-E | Human | Esophagus | ESCC | 3.94e-18 | 4.77e-01 | 0.1149 |
28951 | TRIB2 | P16T-E | Human | Esophagus | ESCC | 4.12e-30 | 6.02e-01 | 0.1153 |
28951 | TRIB2 | P20T-E | Human | Esophagus | ESCC | 9.74e-08 | 1.33e-01 | 0.1124 |
28951 | TRIB2 | P21T-E | Human | Esophagus | ESCC | 2.10e-17 | 3.68e-01 | 0.1617 |
28951 | TRIB2 | P22T-E | Human | Esophagus | ESCC | 6.33e-28 | 4.83e-01 | 0.1236 |
28951 | TRIB2 | P23T-E | Human | Esophagus | ESCC | 3.55e-10 | 3.00e-01 | 0.108 |
28951 | TRIB2 | P24T-E | Human | Esophagus | ESCC | 9.39e-09 | 7.03e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:0032434111 | Esophagus | ESCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 107/8552 | 134/18723 | 4.06e-16 | 2.93e-14 | 107 |
GO:2000058111 | Esophagus | ESCC | regulation of ubiquitin-dependent protein catabolic process | 125/8552 | 164/18723 | 1.17e-15 | 7.76e-14 | 125 |
GO:1903364111 | Esophagus | ESCC | positive regulation of cellular protein catabolic process | 117/8552 | 155/18723 | 3.25e-14 | 1.66e-12 | 117 |
GO:1901800110 | Esophagus | ESCC | positive regulation of proteasomal protein catabolic process | 91/8552 | 114/18723 | 6.74e-14 | 3.34e-12 | 91 |
GO:1903052110 | Esophagus | ESCC | positive regulation of proteolysis involved in cellular protein catabolic process | 101/8552 | 133/18723 | 9.58e-13 | 4.19e-11 | 101 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0051348111 | Esophagus | ESCC | negative regulation of transferase activity | 177/8552 | 268/18723 | 1.08e-11 | 4.00e-10 | 177 |
GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
GO:0032436111 | Esophagus | ESCC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 72/8552 | 90/18723 | 2.30e-11 | 7.87e-10 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIB2 | SNV | Missense_Mutation | c.749G>A | p.Gly250Glu | p.G250E | Q92519 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A1G1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIB2 | SNV | Missense_Mutation | c.448N>A | p.Glu150Lys | p.E150K | Q92519 | protein_coding | tolerated(0.1) | possibly_damaging(0.622) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
TRIB2 | SNV | Missense_Mutation | rs577789476 | c.857N>A | p.Arg286Gln | p.R286Q | Q92519 | protein_coding | tolerated(0.16) | benign(0.158) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIB2 | SNV | Missense_Mutation | novel | c.950N>T | p.Ser317Leu | p.S317L | Q92519 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TRIB2 | SNV | Missense_Mutation | novel | c.536N>A | p.Arg179Gln | p.R179Q | Q92519 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
TRIB2 | SNV | Missense_Mutation | c.535C>T | p.Arg179Trp | p.R179W | Q92519 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRIB2 | SNV | Missense_Mutation | novel | c.782N>T | p.Ser261Phe | p.S261F | Q92519 | protein_coding | deleterious(0.02) | possibly_damaging(0.848) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRIB2 | SNV | Missense_Mutation | rs376273712 | c.940N>A | p.Val314Ile | p.V314I | Q92519 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIB2 | SNV | Missense_Mutation | c.535N>T | p.Arg179Trp | p.R179W | Q92519 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6651-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD | |
TRIB2 | SNV | Missense_Mutation | c.631N>A | p.Asp211Asn | p.D211N | Q92519 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
28951 | TRIB2 | KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | allopurinol | ALLOPURINOL | 30924126 |
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