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Gene: TMEM52 |
Gene summary for TMEM52 |
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Gene information | Species | Human | Gene symbol | TMEM52 | Gene ID | 339456 |
Gene name | transmembrane protein 52 | |
Gene Alias | TMEM52 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NDY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339456 | TMEM52 | LZE24T | Human | Esophagus | ESCC | 9.67e-05 | 2.12e-01 | 0.0596 |
339456 | TMEM52 | P4T-E | Human | Esophagus | ESCC | 9.79e-15 | 3.80e-01 | 0.1323 |
339456 | TMEM52 | P5T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.27e-01 | 0.1327 |
339456 | TMEM52 | P10T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.73e-01 | 0.116 |
339456 | TMEM52 | P12T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.83e-01 | 0.1122 |
339456 | TMEM52 | P15T-E | Human | Esophagus | ESCC | 8.60e-07 | 1.04e-01 | 0.1149 |
339456 | TMEM52 | P20T-E | Human | Esophagus | ESCC | 9.84e-04 | 1.59e-01 | 0.1124 |
339456 | TMEM52 | P21T-E | Human | Esophagus | ESCC | 1.90e-43 | 9.59e-01 | 0.1617 |
339456 | TMEM52 | P23T-E | Human | Esophagus | ESCC | 9.57e-10 | 2.70e-01 | 0.108 |
339456 | TMEM52 | P26T-E | Human | Esophagus | ESCC | 7.90e-03 | 8.78e-02 | 0.1276 |
339456 | TMEM52 | P27T-E | Human | Esophagus | ESCC | 3.75e-03 | 6.25e-02 | 0.1055 |
339456 | TMEM52 | P28T-E | Human | Esophagus | ESCC | 1.59e-30 | 5.40e-01 | 0.1149 |
339456 | TMEM52 | P31T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.77e-02 | 0.1251 |
339456 | TMEM52 | P32T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.12e-01 | 0.1666 |
339456 | TMEM52 | P36T-E | Human | Esophagus | ESCC | 8.96e-03 | 1.01e-01 | 0.1187 |
339456 | TMEM52 | P37T-E | Human | Esophagus | ESCC | 3.92e-06 | 1.17e-01 | 0.1371 |
339456 | TMEM52 | P49T-E | Human | Esophagus | ESCC | 4.39e-03 | 4.84e-01 | 0.1768 |
339456 | TMEM52 | P52T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.83e-01 | 0.1555 |
339456 | TMEM52 | P54T-E | Human | Esophagus | ESCC | 7.01e-08 | 1.30e-01 | 0.0975 |
339456 | TMEM52 | P57T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.35e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM52 | SNV | Missense_Mutation | c.486N>C | p.Lys162Asn | p.K162N | Q8NDY8 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM52 | SNV | Missense_Mutation | rs369655314 | c.245G>A | p.Arg82Gln | p.R82Q | Q8NDY8 | protein_coding | deleterious(0.03) | benign(0.139) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | rs566773598 | c.382N>T | p.Arg128Trp | p.R128W | Q8NDY8 | protein_coding | tolerated(0.05) | possibly_damaging(0.736) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | novel | c.367T>C | p.Tyr123His | p.Y123H | Q8NDY8 | protein_coding | tolerated(0.16) | possibly_damaging(0.878) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | novel | c.190N>A | p.Leu64Ile | p.L64I | Q8NDY8 | protein_coding | tolerated(0.12) | benign(0.071) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | novel | c.584N>T | p.Ser195Leu | p.S195L | Q8NDY8 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | novel | c.579G>T | p.Gln193His | p.Q193H | Q8NDY8 | protein_coding | deleterious(0.04) | possibly_damaging(0.466) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | novel | c.227T>C | p.Val76Ala | p.V76A | Q8NDY8 | protein_coding | tolerated(0.08) | possibly_damaging(0.808) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM52 | SNV | Missense_Mutation | c.620N>A | p.Gly207Asp | p.G207D | Q8NDY8 | protein_coding | deleterious_low_confidence(0) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM52 | SNV | Missense_Mutation | novel | c.346A>G | p.Thr116Ala | p.T116A | Q8NDY8 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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