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Gene: TMEM170B |
Gene summary for TMEM170B |
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Gene information | Species | Human | Gene symbol | TMEM170B | Gene ID | 100113407 |
Gene name | transmembrane protein 170B | |
Gene Alias | TMEM170B | |
Cytomap | 6p24.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q5T4T1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100113407 | TMEM170B | HCC1_Meng | Human | Liver | HCC | 1.49e-14 | 2.12e-02 | 0.0246 |
100113407 | TMEM170B | HCC1 | Human | Liver | HCC | 3.57e-03 | 2.00e+00 | 0.5336 |
100113407 | TMEM170B | HCC2 | Human | Liver | HCC | 4.96e-08 | 2.59e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM170B | SNV | Missense_Mutation | novel | c.289N>C | p.Tyr97His | p.Y97H | Q5T4T1 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM170B | SNV | Missense_Mutation | c.40N>C | p.Ser14Pro | p.S14P | Q5T4T1 | protein_coding | deleterious(0.03) | benign(0.07) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM170B | SNV | Missense_Mutation | c.99N>T | p.Glu33Asp | p.E33D | Q5T4T1 | protein_coding | deleterious(0.01) | benign(0.425) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMEM170B | SNV | Missense_Mutation | c.322N>A | p.Glu108Lys | p.E108K | Q5T4T1 | protein_coding | deleterious(0.03) | possibly_damaging(0.894) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMEM170B | insertion | In_Frame_Ins | novel | c.378_379insTTTCATCAAAAC | p.Ser126_Arg127insPheHisGlnAsn | p.S126_R127insFHQN | Q5T4T1 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM170B | SNV | Missense_Mutation | novel | c.52N>A | p.Val18Ile | p.V18I | Q5T4T1 | protein_coding | tolerated(0.77) | probably_damaging(0.935) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM170B | SNV | Missense_Mutation | c.281N>T | p.Ala94Val | p.A94V | Q5T4T1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM170B | SNV | Missense_Mutation | novel | c.263N>C | p.Ile88Thr | p.I88T | Q5T4T1 | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM170B | SNV | Missense_Mutation | novel | c.295G>A | p.Val99Ile | p.V99I | Q5T4T1 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM170B | deletion | Frame_Shift_Del | c.12delN | p.Gly6AlafsTer5 | p.G6Afs*5 | Q5T4T1 | protein_coding | TCGA-AX-A2IN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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