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Gene: TM4SF1 |
Gene summary for TM4SF1 |
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Gene information | Species | Human | Gene symbol | TM4SF1 | Gene ID | 4071 |
Gene name | transmembrane 4 L six family member 1 | |
Gene Alias | H-L6 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P30408 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4071 | TM4SF1 | GSM4909285 | Human | Breast | IDC | 1.91e-13 | -2.58e-01 | 0.21 |
4071 | TM4SF1 | GSM4909286 | Human | Breast | IDC | 2.11e-40 | -7.85e-01 | 0.1081 |
4071 | TM4SF1 | GSM4909288 | Human | Breast | IDC | 1.47e-09 | -8.36e-01 | 0.0988 |
4071 | TM4SF1 | GSM4909290 | Human | Breast | IDC | 1.77e-23 | -7.54e-01 | 0.2096 |
4071 | TM4SF1 | GSM4909291 | Human | Breast | IDC | 2.42e-18 | -8.10e-01 | 0.1753 |
4071 | TM4SF1 | GSM4909292 | Human | Breast | IDC | 9.83e-07 | -1.04e+00 | 0.1236 |
4071 | TM4SF1 | GSM4909293 | Human | Breast | IDC | 1.17e-32 | -9.59e-01 | 0.1581 |
4071 | TM4SF1 | GSM4909294 | Human | Breast | IDC | 4.13e-40 | -1.06e+00 | 0.2022 |
4071 | TM4SF1 | GSM4909296 | Human | Breast | IDC | 4.94e-34 | -9.91e-01 | 0.1524 |
4071 | TM4SF1 | GSM4909297 | Human | Breast | IDC | 8.18e-07 | -2.60e-01 | 0.1517 |
4071 | TM4SF1 | GSM4909298 | Human | Breast | IDC | 6.09e-44 | -1.10e+00 | 0.1551 |
4071 | TM4SF1 | GSM4909301 | Human | Breast | IDC | 2.33e-70 | -1.38e+00 | 0.1577 |
4071 | TM4SF1 | GSM4909302 | Human | Breast | IDC | 8.60e-62 | -1.23e+00 | 0.1545 |
4071 | TM4SF1 | GSM4909303 | Human | Breast | IDC | 6.20e-09 | -7.92e-01 | 0.0438 |
4071 | TM4SF1 | GSM4909304 | Human | Breast | IDC | 9.59e-88 | -1.48e+00 | 0.1636 |
4071 | TM4SF1 | GSM4909306 | Human | Breast | IDC | 4.84e-32 | -9.15e-01 | 0.1564 |
4071 | TM4SF1 | GSM4909307 | Human | Breast | IDC | 4.86e-06 | -4.43e-01 | 0.1569 |
4071 | TM4SF1 | GSM4909308 | Human | Breast | IDC | 7.85e-22 | -4.88e-01 | 0.158 |
4071 | TM4SF1 | GSM4909311 | Human | Breast | IDC | 8.48e-53 | -1.07e+00 | 0.1534 |
4071 | TM4SF1 | GSM4909312 | Human | Breast | IDC | 5.02e-31 | -9.35e-01 | 0.1552 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TM4SF1 | SNV | Missense_Mutation | rs199669677 | c.290N>G | p.Ala97Gly | p.A97G | P30408 | protein_coding | deleterious(0) | possibly_damaging(0.565) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TM4SF1 | SNV | Missense_Mutation | novel | c.122A>C | p.Asn41Thr | p.N41T | P30408 | protein_coding | tolerated(0.06) | benign(0.122) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TM4SF1 | SNV | Missense_Mutation | novel | c.20N>T | p.Ala7Val | p.A7V | P30408 | protein_coding | deleterious(0) | possibly_damaging(0.749) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TM4SF1 | SNV | Missense_Mutation | c.62N>T | p.Cys21Phe | p.C21F | P30408 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-NH-A8F8-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
TM4SF1 | SNV | Missense_Mutation | novel | c.347C>T | p.Ala116Val | p.A116V | P30408 | protein_coding | tolerated(0.36) | benign(0.026) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TM4SF1 | SNV | Missense_Mutation | c.289N>T | p.Ala97Ser | p.A97S | P30408 | protein_coding | tolerated(0.09) | benign(0.143) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM4SF1 | SNV | Missense_Mutation | c.86N>G | p.Tyr29Cys | p.Y29C | P30408 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TM4SF1 | SNV | Missense_Mutation | c.308G>T | p.Gly103Val | p.G103V | P30408 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
TM4SF1 | SNV | Missense_Mutation | c.229N>T | p.Gly77Cys | p.G77C | P30408 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM4SF1 | SNV | Missense_Mutation | rs745533363 | c.266C>T | p.Ala89Val | p.A89V | P30408 | protein_coding | deleterious(0.05) | possibly_damaging(0.59) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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