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Gene: SSX1 |
Gene summary for SSX1 |
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Gene information | Species | Human | Gene symbol | SSX1 | Gene ID | 6756 |
Gene name | SSX family member 1 | |
Gene Alias | CT5.1 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q16384 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6756 | SSX1 | HCC2 | Human | Liver | HCC | 9.74e-22 | 4.57e+00 | 0.5341 |
6756 | SSX1 | HCC5 | Human | Liver | HCC | 2.02e-03 | 1.43e+00 | 0.4932 |
6756 | SSX1 | S014 | Human | Liver | HCC | 2.64e-07 | 2.72e-01 | 0.2254 |
6756 | SSX1 | S016 | Human | Liver | HCC | 3.39e-02 | 1.17e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSX1 | SNV | Missense_Mutation | c.510N>C | p.Glu170Asp | p.E170D | Q16384 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SSX1 | SNV | Missense_Mutation | c.97N>A | p.Ser33Thr | p.S33T | Q16384 | protein_coding | deleterious(0.01) | possibly_damaging(0.878) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR | |
SSX1 | SNV | Missense_Mutation | rs782580950 | c.98N>T | p.Ser33Phe | p.S33F | Q16384 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
SSX1 | SNV | Missense_Mutation | rs143756961 | c.506N>A | p.Arg169His | p.R169H | Q16384 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-E9-A5UO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SSX1 | insertion | Nonsense_Mutation | novel | c.374_375insGATTTTCCCTTAGCTTATTTTACATGTATTATTCACTATTTCAT | p.Val126IlefsTer4 | p.V126Ifs*4 | Q16384 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
SSX1 | SNV | Missense_Mutation | c.510N>T | p.Glu170Asp | p.E170D | Q16384 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SSX1 | SNV | Missense_Mutation | rs145146460 | c.544N>A | p.Asp182Asn | p.D182N | Q16384 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SSX1 | SNV | Missense_Mutation | novel | c.162C>A | p.Asn54Lys | p.N54K | Q16384 | protein_coding | tolerated(0.47) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SSX1 | SNV | Missense_Mutation | c.398N>T | p.Gln133Leu | p.Q133L | Q16384 | protein_coding | deleterious(0.01) | possibly_damaging(0.775) | TCGA-A5-A0GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SSX1 | SNV | Missense_Mutation | novel | c.354G>T | p.Glu118Asp | p.E118D | Q16384 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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