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Gene: SRRM3 |
Gene summary for SRRM3 |
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Gene information | Species | Human | Gene symbol | SRRM3 | Gene ID | 222183 |
Gene name | serine/arginine repetitive matrix 3 | |
Gene Alias | SRRM3 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A087WXA3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222183 | SRRM3 | LZE4T | Human | Esophagus | ESCC | 1.59e-02 | 1.00e-01 | 0.0811 |
222183 | SRRM3 | LZE21T | Human | Esophagus | ESCC | 1.16e-02 | 2.44e-01 | 0.0655 |
222183 | SRRM3 | P2T-E | Human | Esophagus | ESCC | 9.67e-04 | 9.95e-02 | 0.1177 |
222183 | SRRM3 | P4T-E | Human | Esophagus | ESCC | 2.72e-16 | 4.22e-01 | 0.1323 |
222183 | SRRM3 | P5T-E | Human | Esophagus | ESCC | 8.79e-12 | 1.84e-01 | 0.1327 |
222183 | SRRM3 | P9T-E | Human | Esophagus | ESCC | 3.15e-05 | 1.39e-01 | 0.1131 |
222183 | SRRM3 | P10T-E | Human | Esophagus | ESCC | 7.06e-07 | 9.05e-02 | 0.116 |
222183 | SRRM3 | P12T-E | Human | Esophagus | ESCC | 4.80e-20 | 3.98e-01 | 0.1122 |
222183 | SRRM3 | P15T-E | Human | Esophagus | ESCC | 2.15e-12 | 2.69e-01 | 0.1149 |
222183 | SRRM3 | P16T-E | Human | Esophagus | ESCC | 5.70e-14 | 3.23e-01 | 0.1153 |
222183 | SRRM3 | P20T-E | Human | Esophagus | ESCC | 1.49e-09 | 2.23e-01 | 0.1124 |
222183 | SRRM3 | P22T-E | Human | Esophagus | ESCC | 1.43e-19 | 2.85e-01 | 0.1236 |
222183 | SRRM3 | P23T-E | Human | Esophagus | ESCC | 4.14e-03 | 1.01e-01 | 0.108 |
222183 | SRRM3 | P26T-E | Human | Esophagus | ESCC | 5.44e-16 | 3.24e-01 | 0.1276 |
222183 | SRRM3 | P27T-E | Human | Esophagus | ESCC | 1.39e-10 | 1.52e-01 | 0.1055 |
222183 | SRRM3 | P28T-E | Human | Esophagus | ESCC | 1.07e-25 | 4.17e-01 | 0.1149 |
222183 | SRRM3 | P30T-E | Human | Esophagus | ESCC | 6.51e-15 | 4.40e-01 | 0.137 |
222183 | SRRM3 | P31T-E | Human | Esophagus | ESCC | 1.12e-12 | 2.08e-01 | 0.1251 |
222183 | SRRM3 | P32T-E | Human | Esophagus | ESCC | 7.09e-09 | 1.79e-01 | 0.1666 |
222183 | SRRM3 | P36T-E | Human | Esophagus | ESCC | 9.97e-05 | 1.49e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRRM3 | SNV | Missense_Mutation | novel | c.890N>A | p.Ser297Asn | p.S297N | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-EA-A1QT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SRRM3 | SNV | Missense_Mutation | rs782810649 | c.629N>A | p.Arg210His | p.R210H | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-AD-6963-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SRRM3 | SNV | Missense_Mutation | rs570515153 | c.1852G>A | p.Gly618Arg | p.G618R | protein_coding | tolerated_low_confidence(0.17) | benign(0.024) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SRRM3 | SNV | Missense_Mutation | rs782810649 | c.629N>A | p.Arg210His | p.R210H | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
SRRM3 | SNV | Missense_Mutation | rs190294181 | c.1889N>A | p.Arg630Gln | p.R630Q | protein_coding | tolerated_low_confidence(0.05) | benign(0.015) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
SRRM3 | SNV | Missense_Mutation | novel | c.1862G>T | p.Ser621Ile | p.S621I | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.735) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
SRRM3 | SNV | Missense_Mutation | novel | c.634G>T | p.Asp212Tyr | p.D212Y | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
SRRM3 | SNV | Missense_Mutation | novel | c.647N>A | p.Ser216Tyr | p.S216Y | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
SRRM3 | SNV | Missense_Mutation | novel | c.1898N>A | p.Ser633Asn | p.S633N | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.979) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
SRRM3 | SNV | Missense_Mutation | rs782033133 | c.1867N>T | p.Arg623Cys | p.R623C | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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