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Gene: SMIM27 |
Gene summary for SMIM27 |
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Gene information | Species | Human | Gene symbol | SMIM27 | Gene ID | 100129250 |
Gene name | small integral membrane protein 27 | |
Gene Alias | C9orf133 | |
Cytomap | 9p21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100129250 | SMIM27 | S014 | Human | Liver | HCC | 8.95e-14 | 3.20e-01 | 0.2254 |
100129250 | SMIM27 | S015 | Human | Liver | HCC | 1.17e-21 | 6.17e-01 | 0.2375 |
100129250 | SMIM27 | S016 | Human | Liver | HCC | 2.19e-28 | 5.91e-01 | 0.2243 |
100129250 | SMIM27 | S027 | Human | Liver | HCC | 1.62e-09 | 5.68e-01 | 0.2446 |
100129250 | SMIM27 | S028 | Human | Liver | HCC | 1.65e-17 | 4.48e-01 | 0.2503 |
100129250 | SMIM27 | S029 | Human | Liver | HCC | 1.35e-11 | 3.67e-01 | 0.2581 |
100129250 | SMIM27 | male-WTA | Human | Thyroid | PTC | 3.28e-16 | 2.23e-01 | 0.1037 |
100129250 | SMIM27 | PTC01 | Human | Thyroid | PTC | 5.95e-07 | 1.86e-01 | 0.1899 |
100129250 | SMIM27 | PTC04 | Human | Thyroid | PTC | 5.85e-06 | 1.36e-01 | 0.1927 |
100129250 | SMIM27 | PTC05 | Human | Thyroid | PTC | 4.06e-13 | 4.74e-01 | 0.2065 |
100129250 | SMIM27 | PTC06 | Human | Thyroid | PTC | 7.41e-22 | 4.76e-01 | 0.2057 |
100129250 | SMIM27 | PTC07 | Human | Thyroid | PTC | 1.04e-27 | 5.26e-01 | 0.2044 |
100129250 | SMIM27 | ATC12 | Human | Thyroid | ATC | 2.29e-02 | 9.17e-02 | 0.34 |
100129250 | SMIM27 | ATC4 | Human | Thyroid | ATC | 1.03e-04 | 1.45e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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