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Gene: SLC25A24 |
Gene summary for SLC25A24 |
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Gene information | Species | Human | Gene symbol | SLC25A24 | Gene ID | 29957 |
Gene name | solute carrier family 25 member 24 | |
Gene Alias | APC1 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6NUK1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29957 | SLC25A24 | LZE4T | Human | Esophagus | ESCC | 6.85e-09 | 1.86e-01 | 0.0811 |
29957 | SLC25A24 | LZE24T | Human | Esophagus | ESCC | 8.73e-16 | 3.60e-01 | 0.0596 |
29957 | SLC25A24 | P1T-E | Human | Esophagus | ESCC | 2.72e-11 | 6.60e-01 | 0.0875 |
29957 | SLC25A24 | P2T-E | Human | Esophagus | ESCC | 4.52e-42 | 6.92e-01 | 0.1177 |
29957 | SLC25A24 | P4T-E | Human | Esophagus | ESCC | 7.30e-15 | 3.35e-01 | 0.1323 |
29957 | SLC25A24 | P5T-E | Human | Esophagus | ESCC | 4.53e-20 | 4.14e-01 | 0.1327 |
29957 | SLC25A24 | P8T-E | Human | Esophagus | ESCC | 3.94e-26 | 5.08e-01 | 0.0889 |
29957 | SLC25A24 | P9T-E | Human | Esophagus | ESCC | 2.48e-12 | 1.62e-01 | 0.1131 |
29957 | SLC25A24 | P10T-E | Human | Esophagus | ESCC | 1.39e-22 | 4.57e-01 | 0.116 |
29957 | SLC25A24 | P11T-E | Human | Esophagus | ESCC | 2.98e-09 | 3.74e-01 | 0.1426 |
29957 | SLC25A24 | P12T-E | Human | Esophagus | ESCC | 5.04e-44 | 8.01e-01 | 0.1122 |
29957 | SLC25A24 | P15T-E | Human | Esophagus | ESCC | 1.48e-08 | 8.44e-02 | 0.1149 |
29957 | SLC25A24 | P16T-E | Human | Esophagus | ESCC | 4.15e-14 | 1.15e-01 | 0.1153 |
29957 | SLC25A24 | P17T-E | Human | Esophagus | ESCC | 3.47e-08 | 5.63e-01 | 0.1278 |
29957 | SLC25A24 | P19T-E | Human | Esophagus | ESCC | 8.18e-12 | 6.72e-01 | 0.1662 |
29957 | SLC25A24 | P20T-E | Human | Esophagus | ESCC | 1.89e-13 | 3.68e-01 | 0.1124 |
29957 | SLC25A24 | P21T-E | Human | Esophagus | ESCC | 6.33e-21 | 3.35e-01 | 0.1617 |
29957 | SLC25A24 | P22T-E | Human | Esophagus | ESCC | 6.75e-15 | 1.50e-01 | 0.1236 |
29957 | SLC25A24 | P23T-E | Human | Esophagus | ESCC | 5.38e-25 | 5.01e-01 | 0.108 |
29957 | SLC25A24 | P24T-E | Human | Esophagus | ESCC | 4.50e-12 | 2.37e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:001593114 | Oral cavity | OSCC | nucleobase-containing compound transport | 150/7305 | 222/18723 | 4.86e-18 | 5.04e-16 | 150 |
GO:006219720 | Oral cavity | OSCC | cellular response to chemical stress | 204/7305 | 337/18723 | 6.89e-16 | 5.19e-14 | 204 |
GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
GO:003459920 | Oral cavity | OSCC | cellular response to oxidative stress | 173/7305 | 288/18723 | 2.90e-13 | 1.43e-11 | 173 |
GO:001003820 | Oral cavity | OSCC | response to metal ion | 188/7305 | 373/18723 | 4.34e-06 | 5.00e-05 | 188 |
GO:007124115 | Oral cavity | OSCC | cellular response to inorganic substance | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:19012642 | Oral cavity | OSCC | carbohydrate derivative transport | 44/7305 | 80/18723 | 2.67e-03 | 1.16e-02 | 44 |
GO:007124816 | Oral cavity | OSCC | cellular response to metal ion | 93/7305 | 197/18723 | 1.14e-02 | 3.85e-02 | 93 |
GO:000683919 | Oral cavity | LP | mitochondrial transport | 119/4623 | 254/18723 | 1.06e-14 | 1.33e-12 | 119 |
GO:0006979110 | Oral cavity | LP | response to oxidative stress | 181/4623 | 446/18723 | 5.74e-14 | 6.10e-12 | 181 |
GO:001593115 | Oral cavity | LP | nucleobase-containing compound transport | 95/4623 | 222/18723 | 2.23e-09 | 9.98e-08 | 95 |
GO:0062197110 | Oral cavity | LP | cellular response to chemical stress | 130/4623 | 337/18723 | 8.94e-09 | 3.52e-07 | 130 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A24 | SNV | Missense_Mutation | c.110N>C | p.Gly37Ala | p.G37A | Q6NUK1 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SLC25A24 | SNV | Missense_Mutation | c.1135N>C | p.Asp379His | p.D379H | Q6NUK1 | protein_coding | tolerated(0.07) | benign(0.02) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SLC25A24 | SNV | Missense_Mutation | c.75G>T | p.Glu25Asp | p.E25D | Q6NUK1 | protein_coding | tolerated(0.23) | benign(0.043) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC25A24 | SNV | Missense_Mutation | rs149670605 | c.1298N>A | p.Arg433Gln | p.R433Q | Q6NUK1 | protein_coding | tolerated(0.77) | benign(0.007) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A24 | SNV | Missense_Mutation | novel | c.56N>G | p.Glu19Gly | p.E19G | Q6NUK1 | protein_coding | deleterious(0.05) | benign(0.143) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SLC25A24 | SNV | Missense_Mutation | rs781747926 | c.1235G>A | p.Arg412His | p.R412H | Q6NUK1 | protein_coding | deleterious(0.04) | possibly_damaging(0.839) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A24 | SNV | Missense_Mutation | novel | c.872G>T | p.Arg291Ile | p.R291I | Q6NUK1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A24 | SNV | Missense_Mutation | novel | c.828G>T | p.Lys276Asn | p.K276N | Q6NUK1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A24 | SNV | Missense_Mutation | novel | c.803A>C | p.Lys268Thr | p.K268T | Q6NUK1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A24 | deletion | Frame_Shift_Del | rs763273320 | c.570delA | p.Lys190AsnfsTer29 | p.K190Nfs*29 | Q6NUK1 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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