GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:003253526 | Thyroid | ATC | regulation of cellular component size | 191/6293 | 383/18723 | 2.51e-11 | 8.69e-10 | 191 |
GO:000166731 | Thyroid | ATC | ameboidal-type cell migration | 228/6293 | 475/18723 | 3.72e-11 | 1.22e-09 | 228 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
GO:001097523 | Thyroid | ATC | regulation of neuron projection development | 212/6293 | 445/18723 | 4.16e-10 | 1.14e-08 | 212 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:004867522 | Thyroid | ATC | axon extension | 68/6293 | 120/18723 | 1.73e-07 | 2.75e-06 | 68 |
GO:005076723 | Thyroid | ATC | regulation of neurogenesis | 168/6293 | 364/18723 | 3.73e-07 | 5.48e-06 | 168 |
GO:004876221 | Thyroid | ATC | mesenchymal cell differentiation | 116/6293 | 236/18723 | 5.08e-07 | 7.30e-06 | 116 |
GO:199013824 | Thyroid | ATC | neuron projection extension | 89/6293 | 172/18723 | 6.63e-07 | 9.13e-06 | 89 |
GO:004858823 | Thyroid | ATC | developmental cell growth | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:006056019 | Thyroid | ATC | developmental growth involved in morphogenesis | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:005077011 | Thyroid | ATC | regulation of axonogenesis | 80/6293 | 154/18723 | 1.95e-06 | 2.34e-05 | 80 |
GO:006048521 | Thyroid | ATC | mesenchyme development | 136/6293 | 291/18723 | 2.04e-06 | 2.43e-05 | 136 |
GO:005196014 | Thyroid | ATC | regulation of nervous system development | 195/6293 | 443/18723 | 2.62e-06 | 3.06e-05 | 195 |
GO:000836122 | Thyroid | ATC | regulation of cell size | 89/6293 | 181/18723 | 1.01e-05 | 1.00e-04 | 89 |
GO:004592622 | Thyroid | ATC | negative regulation of growth | 115/6293 | 249/18723 | 2.34e-05 | 2.06e-04 | 115 |
GO:003030813 | Thyroid | ATC | negative regulation of cell growth | 90/6293 | 188/18723 | 3.35e-05 | 2.78e-04 | 90 |
GO:004886321 | Thyroid | ATC | stem cell differentiation | 97/6293 | 206/18723 | 3.88e-05 | 3.15e-04 | 97 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEMA6B | SNV | Missense_Mutation | novel | c.1100A>C | p.Glu367Ala | p.E367A | Q9H3T3 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
SEMA6B | insertion | In_Frame_Ins | novel | c.753_754insCCACCACGCCCGGCCAAGAGTTTCTTC | p.Glu251_Phe252insProProArgProAlaLysSerPhePhe | p.E251_F252insPPRPAKSFF | Q9H3T3 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SEMA6B | deletion | Frame_Shift_Del | | c.826delN | p.Arg276AlafsTer11 | p.R276Afs*11 | Q9H3T3 | protein_coding | | | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEMA6B | deletion | Frame_Shift_Del | novel | c.1308delN | p.Gly437AlafsTer63 | p.G437Afs*63 | Q9H3T3 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
SEMA6B | SNV | Missense_Mutation | rs186951396 | c.1358C>T | p.Thr453Met | p.T453M | Q9H3T3 | protein_coding | tolerated(0.09) | probably_damaging(0.971) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SEMA6B | SNV | Missense_Mutation | novel | c.1450G>A | p.Asp484Asn | p.D484N | Q9H3T3 | protein_coding | tolerated(0.32) | possibly_damaging(0.449) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
SEMA6B | deletion | Frame_Shift_Del | | c.826delC | p.Arg276AlafsTer11 | p.R276Afs*11 | Q9H3T3 | protein_coding | | | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SEMA6B | SNV | Missense_Mutation | | c.1832N>T | p.Ala611Val | p.A611V | Q9H3T3 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA6B | SNV | Missense_Mutation | rs769299847 | c.1126N>A | p.Gly376Arg | p.G376R | Q9H3T3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
SEMA6B | SNV | Missense_Mutation | | c.1852N>A | p.Val618Met | p.V618M | Q9H3T3 | protein_coding | deleterious(0.03) | possibly_damaging(0.461) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |