|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: RPL7P9 |
Gene summary for RPL7P9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RPL7P9 | Gene ID | 653702 |
| Gene name | ribosomal protein L7 pseudogene 9 | |
| Gene Alias | RPL7_3_75 | |
| Cytomap | 1p21.3 | |
| Gene Type | pseudo | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 653702 | RPL7P9 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 4.19e-17 | 7.24e-01 | 0.02 |
| 653702 | RPL7P9 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 7.24e-05 | 5.82e-01 | 0.0267 |
| 653702 | RPL7P9 | PTCwithHT_6 | Human | Thyroid | HT | 2.52e-02 | 1.37e-01 | 0.02 |
| 653702 | RPL7P9 | PTCwithHT_8 | Human | Thyroid | HT | 7.17e-06 | 3.82e-01 | 0.0351 |
| 653702 | RPL7P9 | PTCwithoutHT_2 | Human | Thyroid | PTC | 4.29e-02 | 1.54e-01 | 0.0419 |
| 653702 | RPL7P9 | male-WTA | Human | Thyroid | PTC | 1.73e-47 | -1.28e-01 | 0.1037 |
| 653702 | RPL7P9 | nodule-WTA | Human | Thyroid | goiters | 1.51e-02 | -4.29e-01 | 0.0534 |
| 653702 | RPL7P9 | PTC01 | Human | Thyroid | PTC | 1.68e-15 | -6.28e-01 | 0.1899 |
| 653702 | RPL7P9 | PTC03 | Human | Thyroid | PTC | 1.48e-04 | -6.28e-01 | 0.1784 |
| 653702 | RPL7P9 | PTC04 | Human | Thyroid | PTC | 3.28e-16 | -6.28e-01 | 0.1927 |
| 653702 | RPL7P9 | PTC05 | Human | Thyroid | PTC | 8.49e-05 | -6.28e-01 | 0.2065 |
| 653702 | RPL7P9 | PTC06 | Human | Thyroid | PTC | 3.62e-11 | -6.28e-01 | 0.2057 |
| 653702 | RPL7P9 | PTC07 | Human | Thyroid | PTC | 2.80e-17 | -6.28e-01 | 0.2044 |
| 653702 | RPL7P9 | ATC08 | Human | Thyroid | ATC | 3.15e-04 | -6.28e-01 | 0.0541 |
| 653702 | RPL7P9 | ATC09 | Human | Thyroid | ATC | 4.88e-05 | -6.28e-01 | 0.2871 |
| 653702 | RPL7P9 | ATC12 | Human | Thyroid | ATC | 3.77e-15 | -6.28e-01 | 0.34 |
| 653702 | RPL7P9 | ATC13 | Human | Thyroid | ATC | 6.38e-17 | -6.28e-01 | 0.34 |
| 653702 | RPL7P9 | ATC1 | Human | Thyroid | ATC | 6.76e-04 | -6.28e-01 | 0.2878 |
| 653702 | RPL7P9 | ATC4 | Human | Thyroid | ATC | 3.47e-16 | -6.28e-01 | 0.34 |
| 653702 | RPL7P9 | ATC5 | Human | Thyroid | ATC | 4.70e-13 | -6.28e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Oral cavity | OSCC |  |
| Oral cavity | LP |  |
| Oral cavity | EOLP |  |
| Oral cavity | NEOLP |  |
| Esophagus | HGIN |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |