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Gene: RPL22 |
Gene summary for RPL22 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPL22 | Gene ID | 6146 |
Gene name | ribosomal protein L22 | |
Gene Alias | EAP | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P35268 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6146 | RPL22 | GSM4909282 | Human | Breast | IDC | 1.71e-19 | -2.49e-01 | -0.0288 |
6146 | RPL22 | GSM4909288 | Human | Breast | IDC | 4.99e-10 | 2.63e-01 | 0.0988 |
6146 | RPL22 | GSM4909291 | Human | Breast | IDC | 3.58e-06 | -2.22e-01 | 0.1753 |
6146 | RPL22 | GSM4909294 | Human | Breast | IDC | 1.14e-22 | 2.04e-01 | 0.2022 |
6146 | RPL22 | GSM4909296 | Human | Breast | IDC | 1.38e-04 | 1.06e-01 | 0.1524 |
6146 | RPL22 | GSM4909297 | Human | Breast | IDC | 8.92e-05 | -2.21e-01 | 0.1517 |
6146 | RPL22 | GSM4909301 | Human | Breast | IDC | 2.11e-22 | -3.42e-01 | 0.1577 |
6146 | RPL22 | GSM4909306 | Human | Breast | IDC | 1.43e-05 | -1.40e-01 | 0.1564 |
6146 | RPL22 | GSM4909307 | Human | Breast | IDC | 3.71e-19 | -2.83e-01 | 0.1569 |
6146 | RPL22 | GSM4909308 | Human | Breast | IDC | 4.20e-30 | -3.35e-01 | 0.158 |
6146 | RPL22 | GSM4909309 | Human | Breast | IDC | 4.90e-02 | -2.13e-01 | 0.0483 |
6146 | RPL22 | GSM4909311 | Human | Breast | IDC | 4.59e-33 | -5.08e-01 | 0.1534 |
6146 | RPL22 | GSM4909312 | Human | Breast | IDC | 3.23e-32 | -5.29e-01 | 0.1552 |
6146 | RPL22 | GSM4909313 | Human | Breast | IDC | 2.38e-04 | -2.58e-01 | 0.0391 |
6146 | RPL22 | GSM4909315 | Human | Breast | IDC | 5.89e-20 | 2.24e-01 | 0.21 |
6146 | RPL22 | GSM4909316 | Human | Breast | IDC | 2.16e-10 | 1.56e-01 | 0.21 |
6146 | RPL22 | GSM4909319 | Human | Breast | IDC | 3.39e-70 | -9.45e-01 | 0.1563 |
6146 | RPL22 | GSM4909321 | Human | Breast | IDC | 1.92e-25 | -4.97e-01 | 0.1559 |
6146 | RPL22 | brca1 | Human | Breast | Precancer | 1.12e-09 | -1.37e-01 | -0.0338 |
6146 | RPL22 | brca2 | Human | Breast | Precancer | 2.31e-23 | -2.14e-01 | -0.024 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | |
Oral cavity | LP | |
Oral cavity | EOLP | |
Oral cavity | NEOLP | |
Esophagus | HGIN |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:19031313 | Breast | Precancer | mononuclear cell differentiation | 43/1080 | 426/18723 | 2.61e-04 | 3.84e-03 | 43 |
GO:0030098 | Breast | Precancer | lymphocyte differentiation | 36/1080 | 374/18723 | 1.85e-03 | 1.81e-02 | 36 |
GO:0030217 | Breast | Precancer | T cell differentiation | 26/1080 | 257/18723 | 3.89e-03 | 3.10e-02 | 26 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000641714 | Breast | IDC | regulation of translation | 74/1434 | 468/18723 | 1.67e-09 | 1.53e-07 | 74 |
GO:004211012 | Breast | IDC | T cell activation | 64/1434 | 487/18723 | 1.49e-05 | 3.77e-04 | 64 |
GO:190313111 | Breast | IDC | mononuclear cell differentiation | 51/1434 | 426/18723 | 9.81e-04 | 1.11e-02 | 51 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000641724 | Breast | DCIS | regulation of translation | 72/1390 | 468/18723 | 2.46e-09 | 2.17e-07 | 72 |
GO:004211021 | Breast | DCIS | T cell activation | 65/1390 | 487/18723 | 2.78e-06 | 9.42e-05 | 65 |
GO:19031312 | Breast | DCIS | mononuclear cell differentiation | 51/1390 | 426/18723 | 4.88e-04 | 6.40e-03 | 51 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:00302173 | Cervix | CC | T cell differentiation | 51/2311 | 257/18723 | 3.81e-04 | 3.89e-03 | 51 |
GO:19031314 | Cervix | CC | mononuclear cell differentiation | 76/2311 | 426/18723 | 5.66e-04 | 5.42e-03 | 76 |
GO:00300981 | Cervix | CC | lymphocyte differentiation | 63/2311 | 374/18723 | 6.21e-03 | 3.52e-02 | 63 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL22 | SNV | Missense_Mutation | c.301N>T | p.Arg101Cys | p.R101C | P35268 | protein_coding | deleterious(0.05) | benign(0.018) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
RPL22 | SNV | Missense_Mutation | novel | c.268N>C | p.Tyr90His | p.Y90H | P35268 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RPL22 | insertion | Frame_Shift_Ins | rs777006564 | c.44dupA | p.Lys16GlufsTer9 | p.K16Efs*9 | P35268 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
RPL22 | insertion | Frame_Shift_Ins | rs777006564 | c.44dupA | p.Lys16GlufsTer9 | p.K16Efs*9 | P35268 | protein_coding | TCGA-CM-6165-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
RPL22 | insertion | Frame_Shift_Ins | rs752855455 | c.35_36insG | p.Lys13GlnfsTer12 | p.K13Qfs*12 | P35268 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RPL22 | SNV | Missense_Mutation | novel | c.361N>A | p.Glu121Lys | p.E121K | P35268 | protein_coding | tolerated(0.09) | probably_damaging(0.974) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL22 | SNV | Missense_Mutation | c.266N>C | p.Lys89Thr | p.K89T | P35268 | protein_coding | deleterious(0.02) | benign(0.012) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
RPL22 | SNV | Missense_Mutation | c.264N>C | p.Lys88Asn | p.K88N | P35268 | protein_coding | deleterious(0.02) | probably_damaging(0.924) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPL22 | SNV | Missense_Mutation | c.116T>A | p.Phe39Tyr | p.F39Y | P35268 | protein_coding | deleterious(0.02) | probably_damaging(0.926) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
RPL22 | SNV | Missense_Mutation | c.302G>A | p.Arg101His | p.R101H | P35268 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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