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Gene: RNH1 |
Gene summary for RNH1 |
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Gene information | Species | Human | Gene symbol | RNH1 | Gene ID | 6050 |
Gene name | ribonuclease/angiogenin inhibitor 1 | |
Gene Alias | RAI | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | A0A140VJT8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6050 | RNH1 | CA_HPV_1 | Human | Cervix | CC | 2.87e-04 | 3.17e-02 | 0.0264 |
6050 | RNH1 | CA_HPV_3 | Human | Cervix | CC | 2.62e-07 | 3.05e-01 | 0.0414 |
6050 | RNH1 | N_HPV_2 | Human | Cervix | N_HPV | 3.28e-02 | 1.58e-01 | -0.0131 |
6050 | RNH1 | CCI_1 | Human | Cervix | CC | 3.43e-05 | -5.58e-01 | 0.528 |
6050 | RNH1 | CCI_3 | Human | Cervix | CC | 4.38e-06 | -5.27e-01 | 0.516 |
6050 | RNH1 | CCII_1 | Human | Cervix | CC | 3.82e-13 | -5.85e-01 | 0.3249 |
6050 | RNH1 | Tumor | Human | Cervix | CC | 4.71e-05 | 2.66e-01 | 0.1241 |
6050 | RNH1 | sample3 | Human | Cervix | CC | 9.00e-08 | 2.36e-01 | 0.1387 |
6050 | RNH1 | L1 | Human | Cervix | CC | 1.86e-03 | -1.53e-01 | 0.0802 |
6050 | RNH1 | T1 | Human | Cervix | CC | 2.87e-03 | -3.27e-01 | 0.0918 |
6050 | RNH1 | T3 | Human | Cervix | CC | 6.50e-08 | 2.48e-01 | 0.1389 |
6050 | RNH1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.60e-09 | 3.20e-01 | 0.0155 |
6050 | RNH1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.26e-13 | 6.26e-01 | -0.1808 |
6050 | RNH1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.93e-09 | 4.75e-01 | -0.0811 |
6050 | RNH1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.98e-10 | 4.43e-01 | -0.1088 |
6050 | RNH1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.26e-17 | 4.82e-01 | -0.1954 |
6050 | RNH1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.75e-06 | 1.01e+00 | -0.2602 |
6050 | RNH1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.12e-06 | 4.50e-01 | -0.1207 |
6050 | RNH1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.69e-06 | 4.42e-01 | -0.1526 |
6050 | RNH1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.15e-13 | 5.17e-01 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064029 | Cervix | CC | mRNA catabolic process | 56/2311 | 232/18723 | 4.81e-07 | 1.83e-05 | 56 |
GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
GO:00346559 | Cervix | CC | nucleobase-containing compound catabolic process | 74/2311 | 407/18723 | 3.77e-04 | 3.88e-03 | 74 |
GO:00442709 | Cervix | CC | cellular nitrogen compound catabolic process | 79/2311 | 451/18723 | 7.80e-04 | 6.91e-03 | 79 |
GO:00194398 | Cervix | CC | aromatic compound catabolic process | 79/2311 | 467/18723 | 2.14e-03 | 1.54e-02 | 79 |
GO:19013423 | Cervix | CC | regulation of vasculature development | 60/2311 | 348/18723 | 4.48e-03 | 2.72e-02 | 60 |
GO:00457653 | Cervix | CC | regulation of angiogenesis | 59/2311 | 342/18723 | 4.73e-03 | 2.83e-02 | 59 |
GO:19013618 | Cervix | CC | organic cyclic compound catabolic process | 80/2311 | 495/18723 | 6.77e-03 | 3.72e-02 | 80 |
GO:004576521 | Cervix | N_HPV | regulation of angiogenesis | 25/534 | 342/18723 | 1.80e-05 | 5.30e-04 | 25 |
GO:190134221 | Cervix | N_HPV | regulation of vasculature development | 25/534 | 348/18723 | 2.41e-05 | 6.66e-04 | 25 |
GO:000640214 | Cervix | N_HPV | mRNA catabolic process | 17/534 | 232/18723 | 3.76e-04 | 5.43e-03 | 17 |
GO:000640114 | Cervix | N_HPV | RNA catabolic process | 17/534 | 278/18723 | 2.72e-03 | 2.39e-02 | 17 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNH1 | SNV | Missense_Mutation | rs145455574 | c.464N>T | p.Ser155Leu | p.S155L | P13489 | protein_coding | deleterious(0) | benign(0.061) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
RNH1 | SNV | Missense_Mutation | novel | c.1082N>C | p.Leu361Pro | p.L361P | P13489 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD |
RNH1 | deletion | Frame_Shift_Del | novel | c.1083delN | p.Cys362AlafsTer21 | p.C362Afs*21 | P13489 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD | ||
RNH1 | deletion | Frame_Shift_Del | novel | c.335delN | p.Leu112ArgfsTer83 | p.L112Rfs*83 | P13489 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RNH1 | SNV | Missense_Mutation | rs200324639 | c.190N>T | p.Arg64Cys | p.R64C | P13489 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RNH1 | SNV | Missense_Mutation | rs142171562 | c.683N>T | p.Ser228Leu | p.S228L | P13489 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RNH1 | SNV | Missense_Mutation | c.670N>A | p.Ala224Thr | p.A224T | P13489 | protein_coding | deleterious(0.05) | probably_damaging(0.92) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
RNH1 | SNV | Missense_Mutation | rs746696140 | c.1072N>A | p.Val358Met | p.V358M | P13489 | protein_coding | tolerated(0.06) | possibly_damaging(0.528) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
RNH1 | SNV | Missense_Mutation | rs200324639 | c.190N>T | p.Arg64Cys | p.R64C | P13489 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
RNH1 | SNV | Missense_Mutation | rs762505688 | c.527N>T | p.Thr176Met | p.T176M | P13489 | protein_coding | tolerated(0.14) | possibly_damaging(0.451) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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