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Gene: RABGGTB |
Gene summary for RABGGTB |
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Gene information | Species | Human | Gene symbol | RABGGTB | Gene ID | 5876 |
Gene name | Rab geranylgeranyltransferase subunit beta | |
Gene Alias | GGTB | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A8KAJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5876 | RABGGTB | LZE4T | Human | Esophagus | ESCC | 1.16e-10 | 3.04e-01 | 0.0811 |
5876 | RABGGTB | LZE7T | Human | Esophagus | ESCC | 6.48e-08 | 3.69e-01 | 0.0667 |
5876 | RABGGTB | LZE8T | Human | Esophagus | ESCC | 6.23e-10 | 4.24e-01 | 0.067 |
5876 | RABGGTB | LZE20T | Human | Esophagus | ESCC | 1.05e-02 | 1.47e-01 | 0.0662 |
5876 | RABGGTB | LZE24T | Human | Esophagus | ESCC | 6.90e-17 | 4.99e-01 | 0.0596 |
5876 | RABGGTB | LZE21T | Human | Esophagus | ESCC | 1.09e-06 | 1.71e-01 | 0.0655 |
5876 | RABGGTB | LZE6T | Human | Esophagus | ESCC | 3.95e-11 | 2.96e-01 | 0.0845 |
5876 | RABGGTB | P1T-E | Human | Esophagus | ESCC | 1.00e-06 | 2.53e-01 | 0.0875 |
5876 | RABGGTB | P2T-E | Human | Esophagus | ESCC | 4.92e-38 | 8.13e-01 | 0.1177 |
5876 | RABGGTB | P4T-E | Human | Esophagus | ESCC | 6.44e-33 | 7.16e-01 | 0.1323 |
5876 | RABGGTB | P5T-E | Human | Esophagus | ESCC | 3.23e-26 | 6.25e-01 | 0.1327 |
5876 | RABGGTB | P8T-E | Human | Esophagus | ESCC | 1.50e-33 | 5.85e-01 | 0.0889 |
5876 | RABGGTB | P9T-E | Human | Esophagus | ESCC | 4.43e-17 | 5.30e-01 | 0.1131 |
5876 | RABGGTB | P10T-E | Human | Esophagus | ESCC | 2.66e-27 | 6.06e-01 | 0.116 |
5876 | RABGGTB | P11T-E | Human | Esophagus | ESCC | 3.71e-24 | 9.13e-01 | 0.1426 |
5876 | RABGGTB | P12T-E | Human | Esophagus | ESCC | 2.74e-19 | 5.26e-01 | 0.1122 |
5876 | RABGGTB | P15T-E | Human | Esophagus | ESCC | 9.40e-31 | 7.43e-01 | 0.1149 |
5876 | RABGGTB | P16T-E | Human | Esophagus | ESCC | 1.78e-17 | 4.21e-01 | 0.1153 |
5876 | RABGGTB | P17T-E | Human | Esophagus | ESCC | 1.01e-07 | 6.18e-01 | 0.1278 |
5876 | RABGGTB | P19T-E | Human | Esophagus | ESCC | 4.81e-12 | 1.02e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RABGGTB | SNV | Missense_Mutation | novel | c.553N>A | p.Pro185Thr | p.P185T | P53611 | protein_coding | deleterious(0.01) | possibly_damaging(0.762) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
RABGGTB | SNV | Missense_Mutation | c.221N>A | p.Phe74Tyr | p.F74Y | P53611 | protein_coding | tolerated(0.23) | benign(0.096) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
RABGGTB | SNV | Missense_Mutation | novel | c.124T>C | p.Ser42Pro | p.S42P | P53611 | protein_coding | deleterious(0) | possibly_damaging(0.518) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RABGGTB | SNV | Missense_Mutation | c.418G>A | p.Glu140Lys | p.E140K | P53611 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RABGGTB | SNV | Missense_Mutation | rs750012267 | c.194G>A | p.Arg65His | p.R65H | P53611 | protein_coding | deleterious(0.04) | possibly_damaging(0.522) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RABGGTB | SNV | Missense_Mutation | c.338T>C | p.Val113Ala | p.V113A | P53611 | protein_coding | tolerated(0.7) | benign(0) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
RABGGTB | SNV | Missense_Mutation | novel | c.308N>T | p.Gln103Leu | p.Q103L | P53611 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RABGGTB | SNV | Missense_Mutation | rs761094098 | c.505N>A | p.Glu169Lys | p.E169K | P53611 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RABGGTB | SNV | Missense_Mutation | c.827G>A | p.Gly276Glu | p.G276E | P53611 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-F4-6805-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
RABGGTB | SNV | Missense_Mutation | c.781G>C | p.Glu261Gln | p.E261Q | P53611 | protein_coding | tolerated(0.12) | benign(0.282) | TCGA-EI-7004-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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