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Gene: PVRL4 |
Gene summary for PVRL4 |
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Gene information | Species | Human | Gene symbol | PVRL4 | Gene ID | 81607 |
Gene name | nectin cell adhesion molecule 4 | |
Gene Alias | EDSS1 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | K4PZ75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81607 | PVRL4 | P1T-E | Human | Esophagus | ESCC | 1.97e-23 | 1.31e+00 | 0.0875 |
81607 | PVRL4 | P2T-E | Human | Esophagus | ESCC | 1.30e-15 | 3.92e-01 | 0.1177 |
81607 | PVRL4 | P4T-E | Human | Esophagus | ESCC | 1.08e-40 | 1.08e+00 | 0.1323 |
81607 | PVRL4 | P5T-E | Human | Esophagus | ESCC | 1.51e-34 | 7.07e-01 | 0.1327 |
81607 | PVRL4 | P8T-E | Human | Esophagus | ESCC | 3.87e-34 | 6.83e-01 | 0.0889 |
81607 | PVRL4 | P9T-E | Human | Esophagus | ESCC | 9.99e-45 | 1.12e+00 | 0.1131 |
81607 | PVRL4 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.94e-01 | 0.1426 |
81607 | PVRL4 | P12T-E | Human | Esophagus | ESCC | 4.16e-22 | 5.11e-01 | 0.1122 |
81607 | PVRL4 | P15T-E | Human | Esophagus | ESCC | 1.57e-28 | 7.94e-01 | 0.1149 |
81607 | PVRL4 | P17T-E | Human | Esophagus | ESCC | 7.64e-08 | 4.01e-01 | 0.1278 |
81607 | PVRL4 | P20T-E | Human | Esophagus | ESCC | 2.73e-21 | 6.22e-01 | 0.1124 |
81607 | PVRL4 | P21T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.56e-01 | 0.1617 |
81607 | PVRL4 | P22T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.45e-01 | 0.1236 |
81607 | PVRL4 | P23T-E | Human | Esophagus | ESCC | 2.66e-57 | 1.48e+00 | 0.108 |
81607 | PVRL4 | P24T-E | Human | Esophagus | ESCC | 2.56e-16 | 3.75e-01 | 0.1287 |
81607 | PVRL4 | P26T-E | Human | Esophagus | ESCC | 2.03e-57 | 1.11e+00 | 0.1276 |
81607 | PVRL4 | P27T-E | Human | Esophagus | ESCC | 1.23e-20 | 5.68e-01 | 0.1055 |
81607 | PVRL4 | P28T-E | Human | Esophagus | ESCC | 5.87e-84 | 1.61e+00 | 0.1149 |
81607 | PVRL4 | P30T-E | Human | Esophagus | ESCC | 1.16e-21 | 9.37e-01 | 0.137 |
81607 | PVRL4 | P31T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.66e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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