![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PRR15 |
Gene summary for PRR15 |
![]() |
Gene information | Species | Human | Gene symbol | PRR15 | Gene ID | 222171 |
Gene name | proline rich 15 | |
Gene Alias | PRR15 | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A4D1A1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222171 | PRR15 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.57e-12 | 5.25e-01 | -0.1808 |
222171 | PRR15 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.42e-07 | 5.42e-01 | -0.0811 |
222171 | PRR15 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.74e-24 | 7.55e-01 | -0.1088 |
222171 | PRR15 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.99e-32 | 8.45e-01 | -0.1954 |
222171 | PRR15 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.14e-05 | 7.62e-01 | -0.2602 |
222171 | PRR15 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.17e-02 | 6.13e-01 | -0.2196 |
222171 | PRR15 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.20e-05 | 2.63e-01 | -0.1207 |
222171 | PRR15 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.98e-02 | 3.49e-01 | -0.1526 |
222171 | PRR15 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.75e-19 | 5.89e-01 | -0.1464 |
222171 | PRR15 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.16e-09 | 3.26e-01 | -0.1001 |
222171 | PRR15 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.87e-15 | 5.68e-01 | -0.059 |
222171 | PRR15 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.70e-13 | 9.95e-01 | -0.2061 |
222171 | PRR15 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.85e-04 | 4.02e-01 | -0.0842 |
222171 | PRR15 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.88e-27 | 7.55e-01 | 0.096 |
222171 | PRR15 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.04e-07 | 4.13e-01 | 0.0338 |
222171 | PRR15 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-19 | 5.28e-01 | 0.0674 |
222171 | PRR15 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.99e-02 | 4.47e-01 | 0.0112 |
222171 | PRR15 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.50e-05 | 9.10e-01 | -0.0124 |
222171 | PRR15 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.34e-02 | 2.92e-01 | 0.0588 |
222171 | PRR15 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.43e-11 | 3.53e-01 | 0.294 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRR15 | SNV | Missense_Mutation | novel | c.128N>T | p.Thr43Met | p.T43M | Q8IV56 | protein_coding | tolerated(0.1) | benign(0.433) | TCGA-AC-A4ZE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRR15 | SNV | Missense_Mutation | c.344N>T | p.Pro115Leu | p.P115L | Q8IV56 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-EK-A2GZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
PRR15 | SNV | Missense_Mutation | c.88G>T | p.Gly30Trp | p.G30W | Q8IV56 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRR15 | SNV | Missense_Mutation | novel | c.378N>T | p.Glu126Asp | p.E126D | Q8IV56 | protein_coding | tolerated_low_confidence(0.44) | benign(0.011) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRR15 | SNV | Missense_Mutation | novel | c.37N>C | p.Trp13Arg | p.W13R | Q8IV56 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-44-6776-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRR15 | SNV | Missense_Mutation | c.344C>T | p.Pro115Leu | p.P115L | Q8IV56 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |