GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:0035304111 | Esophagus | ESCC | regulation of protein dephosphorylation | 66/8552 | 90/18723 | 8.82e-08 | 1.48e-06 | 66 |
GO:0035303111 | Esophagus | ESCC | regulation of dephosphorylation | 88/8552 | 128/18723 | 1.04e-07 | 1.71e-06 | 88 |
GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
GO:0051346110 | Esophagus | ESCC | negative regulation of hydrolase activity | 208/8552 | 379/18723 | 1.76e-04 | 1.14e-03 | 208 |
GO:003530816 | Esophagus | ESCC | negative regulation of protein dephosphorylation | 26/8552 | 34/18723 | 2.53e-04 | 1.55e-03 | 26 |
GO:0043666110 | Esophagus | ESCC | regulation of phosphoprotein phosphatase activity | 40/8552 | 58/18723 | 2.83e-04 | 1.71e-03 | 40 |
GO:00353056 | Esophagus | ESCC | negative regulation of dephosphorylation | 31/8552 | 45/18723 | 1.40e-03 | 6.62e-03 | 31 |
GO:001092115 | Esophagus | ESCC | regulation of phosphatase activity | 52/8552 | 84/18723 | 1.98e-03 | 8.90e-03 | 52 |
GO:00325155 | Esophagus | ESCC | negative regulation of phosphoprotein phosphatase activity | 19/8552 | 26/18723 | 4.31e-03 | 1.71e-02 | 19 |
GO:000647012 | Lung | AIS | protein dephosphorylation | 56/1849 | 281/18723 | 2.47e-07 | 2.24e-05 | 56 |
GO:004593613 | Lung | AIS | negative regulation of phosphate metabolic process | 75/1849 | 441/18723 | 1.93e-06 | 1.12e-04 | 75 |
GO:001056313 | Lung | AIS | negative regulation of phosphorus metabolic process | 75/1849 | 442/18723 | 2.11e-06 | 1.20e-04 | 75 |
GO:001631112 | Lung | AIS | dephosphorylation | 69/1849 | 417/18723 | 1.27e-05 | 4.78e-04 | 69 |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
GO:003530313 | Lung | AIS | regulation of dephosphorylation | 25/1849 | 128/18723 | 6.76e-04 | 1.01e-02 | 25 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP4R4 | SNV | Missense_Mutation | | c.1002G>C | p.Leu334Phe | p.L334F | Q6NUP7 | protein_coding | tolerated(0.1) | benign(0.042) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PPP4R4 | SNV | Missense_Mutation | novel | c.1471G>A | p.Glu491Lys | p.E491K | Q6NUP7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PPP4R4 | SNV | Missense_Mutation | novel | c.2452G>A | p.Asp818Asn | p.D818N | Q6NUP7 | protein_coding | deleterious_low_confidence(0.03) | benign(0.011) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PPP4R4 | SNV | Missense_Mutation | | c.2513N>C | p.Leu838Ser | p.L838S | Q6NUP7 | protein_coding | tolerated_low_confidence(0.28) | benign(0.241) | TCGA-A2-A0SW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD |
PPP4R4 | SNV | Missense_Mutation | | c.1351N>T | p.Asp451Tyr | p.D451Y | Q6NUP7 | protein_coding | deleterious(0) | possibly_damaging(0.846) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP4R4 | SNV | Missense_Mutation | novel | c.2427N>T | p.Lys809Asn | p.K809N | Q6NUP7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.526) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP4R4 | SNV | Missense_Mutation | novel | c.1384G>A | p.Glu462Lys | p.E462K | Q6NUP7 | protein_coding | tolerated(0.07) | possibly_damaging(0.595) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PPP4R4 | SNV | Missense_Mutation | rs759244525 | c.1754N>A | p.Arg585Gln | p.R585Q | Q6NUP7 | protein_coding | tolerated(0.2) | possibly_damaging(0.78) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP4R4 | SNV | Missense_Mutation | | c.2506A>G | p.Thr836Ala | p.T836A | Q6NUP7 | protein_coding | tolerated_low_confidence(0.24) | benign(0) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PPP4R4 | SNV | Missense_Mutation | | c.1822N>G | p.Leu608Val | p.L608V | Q6NUP7 | protein_coding | tolerated(1) | benign(0.111) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |