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Gene: PHF11 |
Gene summary for PHF11 |
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Gene information | Species | Human | Gene symbol | PHF11 | Gene ID | 51131 |
Gene name | PHD finger protein 11 | |
Gene Alias | APY | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DDL5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51131 | PHF11 | LZE4T | Human | Esophagus | ESCC | 6.18e-04 | 2.30e-01 | 0.0811 |
51131 | PHF11 | LZE7T | Human | Esophagus | ESCC | 1.40e-07 | 2.85e-01 | 0.0667 |
51131 | PHF11 | LZE8T | Human | Esophagus | ESCC | 6.45e-03 | 1.29e-01 | 0.067 |
51131 | PHF11 | LZE20T | Human | Esophagus | ESCC | 1.74e-05 | 2.17e-01 | 0.0662 |
51131 | PHF11 | LZE22T | Human | Esophagus | ESCC | 1.51e-02 | 2.48e-01 | 0.068 |
51131 | PHF11 | LZE24T | Human | Esophagus | ESCC | 4.55e-14 | 3.06e-01 | 0.0596 |
51131 | PHF11 | P1T-E | Human | Esophagus | ESCC | 5.07e-10 | 5.13e-01 | 0.0875 |
51131 | PHF11 | P2T-E | Human | Esophagus | ESCC | 1.33e-21 | 3.70e-01 | 0.1177 |
51131 | PHF11 | P4T-E | Human | Esophagus | ESCC | 4.49e-06 | 1.46e-01 | 0.1323 |
51131 | PHF11 | P5T-E | Human | Esophagus | ESCC | 1.82e-10 | 2.59e-01 | 0.1327 |
51131 | PHF11 | P8T-E | Human | Esophagus | ESCC | 2.95e-22 | 3.46e-01 | 0.0889 |
51131 | PHF11 | P9T-E | Human | Esophagus | ESCC | 2.26e-19 | 4.33e-01 | 0.1131 |
51131 | PHF11 | P11T-E | Human | Esophagus | ESCC | 9.99e-14 | 6.12e-01 | 0.1426 |
51131 | PHF11 | P12T-E | Human | Esophagus | ESCC | 1.71e-20 | 2.56e-01 | 0.1122 |
51131 | PHF11 | P15T-E | Human | Esophagus | ESCC | 1.59e-18 | 4.34e-01 | 0.1149 |
51131 | PHF11 | P16T-E | Human | Esophagus | ESCC | 4.67e-18 | 1.96e-01 | 0.1153 |
51131 | PHF11 | P17T-E | Human | Esophagus | ESCC | 4.72e-04 | 4.07e-01 | 0.1278 |
51131 | PHF11 | P19T-E | Human | Esophagus | ESCC | 9.43e-05 | 6.76e-01 | 0.1662 |
51131 | PHF11 | P20T-E | Human | Esophagus | ESCC | 1.24e-17 | 3.59e-01 | 0.1124 |
51131 | PHF11 | P21T-E | Human | Esophagus | ESCC | 6.48e-22 | 3.73e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF11 | SNV | Missense_Mutation | c.585N>C | p.Met195Ile | p.M195I | Q9UIL8 | protein_coding | tolerated(0.28) | benign(0.023) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PHF11 | SNV | Missense_Mutation | novel | c.446G>A | p.Arg149Gln | p.R149Q | Q9UIL8 | protein_coding | tolerated(0.52) | benign(0.007) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PHF11 | SNV | Missense_Mutation | c.726N>G | p.His242Gln | p.H242Q | Q9UIL8 | protein_coding | deleterious(0.04) | benign(0.05) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
PHF11 | SNV | Missense_Mutation | novel | c.751N>C | p.Glu251Gln | p.E251Q | Q9UIL8 | protein_coding | deleterious(0.01) | possibly_damaging(0.69) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PHF11 | SNV | Missense_Mutation | novel | c.950N>C | p.Arg317Thr | p.R317T | Q9UIL8 | protein_coding | tolerated(0.25) | benign(0.307) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHF11 | SNV | Missense_Mutation | novel | c.554N>T | p.Ser185Leu | p.S185L | Q9UIL8 | protein_coding | tolerated(0.11) | benign(0.276) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHF11 | SNV | Missense_Mutation | novel | c.286N>A | p.Glu96Lys | p.E96K | Q9UIL8 | protein_coding | tolerated(0.45) | benign(0.047) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
PHF11 | SNV | Missense_Mutation | rs767620664 | c.380G>A | p.Cys127Tyr | p.C127Y | Q9UIL8 | protein_coding | deleterious(0.02) | benign(0.072) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
PHF11 | SNV | Missense_Mutation | rs758665562 | c.157N>A | p.Glu53Lys | p.E53K | Q9UIL8 | protein_coding | tolerated(0.1) | benign(0.03) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PHF11 | SNV | Missense_Mutation | novel | c.203N>G | p.His68Arg | p.H68R | Q9UIL8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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