GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003286821 | Liver | HCC | response to insulin | 172/7958 | 264/18723 | 7.14e-14 | 4.23e-12 | 172 |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:000974322 | Liver | HCC | response to carbohydrate | 149/7958 | 253/18723 | 9.55e-08 | 1.89e-06 | 149 |
GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:003428422 | Liver | HCC | response to monosaccharide | 131/7958 | 225/18723 | 1.32e-06 | 1.91e-05 | 131 |
GO:000974622 | Liver | HCC | response to hexose | 126/7958 | 219/18723 | 4.81e-06 | 6.06e-05 | 126 |
GO:000974912 | Liver | HCC | response to glucose | 121/7958 | 212/18723 | 1.24e-05 | 1.39e-04 | 121 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:009730522 | Liver | HCC | response to alcohol | 138/7958 | 253/18723 | 6.91e-05 | 6.26e-04 | 138 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:004259322 | Liver | HCC | glucose homeostasis | 137/7958 | 258/18723 | 3.59e-04 | 2.49e-03 | 137 |
GO:003350022 | Liver | HCC | carbohydrate homeostasis | 137/7958 | 259/18723 | 4.45e-04 | 2.98e-03 | 137 |
GO:000167822 | Liver | HCC | cellular glucose homeostasis | 95/7958 | 172/18723 | 4.95e-04 | 3.24e-03 | 95 |
GO:007133112 | Liver | HCC | cellular response to hexose stimulus | 85/7958 | 153/18723 | 7.47e-04 | 4.52e-03 | 85 |
GO:007133312 | Liver | HCC | cellular response to glucose stimulus | 84/7958 | 151/18723 | 7.57e-04 | 4.56e-03 | 84 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:007132612 | Liver | HCC | cellular response to monosaccharide stimulus | 85/7958 | 154/18723 | 9.78e-04 | 5.68e-03 | 85 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OPRK1 | SNV | Missense_Mutation | rs369742092 | c.853N>A | p.Val285Ile | p.V285I | P41145 | protein_coding | tolerated(0.68) | benign(0.03) | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
OPRK1 | SNV | Missense_Mutation | rs200672427 | c.755N>A | p.Arg252His | p.R252H | P41145 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0TV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OPRK1 | SNV | Missense_Mutation | novel | c.233C>T | p.Ser78Leu | p.S78L | P41145 | protein_coding | tolerated(0.4) | benign(0.006) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
OPRK1 | SNV | Missense_Mutation | rs199564432 | c.613N>A | p.Val205Ile | p.V205I | P41145 | protein_coding | tolerated(0.42) | benign(0) | TCGA-E2-A1IU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
OPRK1 | insertion | Nonsense_Mutation | novel | c.503_504insTATGATTAATCACACATAGGATTTTGTTTCTTCATGCCTAC | p.Phe169MetfsTer6 | p.F169Mfs*6 | P41145 | protein_coding | | | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
OPRK1 | insertion | Nonsense_Mutation | novel | c.972_973insGGAGAGGAAGGTGTTTTGCTTCTGTAGATCTCAAGGTA | p.Leu325GlyfsTer9 | p.L325Gfs*9 | P41145 | protein_coding | | | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
OPRK1 | insertion | Nonsense_Mutation | novel | c.258-1_258insTATATGTGTGTGTATTATGTGAGGATTCATAGTCTGCTC | p.Arg86_Tyr87insIleCysValCysIleMetTerGlyPheIleValCysSer | p.R86_Y87insICVCIM*GFIVCS | P41145 | protein_coding | | | TCGA-AO-A0J3-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | SD |
OPRK1 | SNV | Missense_Mutation | novel | c.886N>A | p.Val296Met | p.V296M | P41145 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
OPRK1 | SNV | Missense_Mutation | | c.211N>A | p.Val71Ile | p.V71I | P41145 | protein_coding | tolerated(0.25) | benign(0.051) | TCGA-AA-3488-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
OPRK1 | SNV | Missense_Mutation | | c.1061N>A | p.Arg354Gln | p.R354Q | P41145 | protein_coding | tolerated(0.8) | benign(0) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650321 | | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | | COCAINE | COCAINE | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | partial agonist | CHEMBL2062276 | LEVALLORPHAN TARTRATE | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | | SALVINORIN A | SALVINORIN A | 22204910 |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | | HYDROMORPHONE | HYDROMORPHONE | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651213 | | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650582 | | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135650689 | NALTRINDOLE | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 178100466 | | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135650868 | QUADAZOCINE | |