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Gene: NOMO2 |
Gene summary for NOMO2 |
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Gene information | Species | Human | Gene symbol | NOMO2 | Gene ID | 283820 |
Gene name | NODAL modulator 2 | |
Gene Alias | Nomo | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5JPE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283820 | NOMO2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.08e-10 | 3.39e-01 | 0.0155 |
283820 | NOMO2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-12 | 5.31e-01 | -0.1808 |
283820 | NOMO2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.68e-02 | 4.41e-01 | 0.0216 |
283820 | NOMO2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.10e-21 | 8.00e-01 | -0.0811 |
283820 | NOMO2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.11e-19 | 6.63e-01 | -0.1088 |
283820 | NOMO2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.85e-42 | 9.05e-01 | -0.1954 |
283820 | NOMO2 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.90e-07 | 9.26e-01 | -0.2602 |
283820 | NOMO2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.24e-05 | 6.32e-01 | -0.2196 |
283820 | NOMO2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.35e-10 | 5.34e-01 | -0.1207 |
283820 | NOMO2 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.21e-18 | 7.89e-01 | -0.1526 |
283820 | NOMO2 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.15e-38 | 9.31e-01 | -0.1464 |
283820 | NOMO2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.93e-25 | 6.59e-01 | -0.1001 |
283820 | NOMO2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.10e-35 | 1.07e+00 | -0.059 |
283820 | NOMO2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.87e-05 | 5.63e-01 | -0.1706 |
283820 | NOMO2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.11e-06 | 5.71e-01 | -0.2061 |
283820 | NOMO2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.27e-03 | 5.11e-01 | -0.1462 |
283820 | NOMO2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.40e-09 | 5.06e-01 | -0.0842 |
283820 | NOMO2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.78e-08 | 5.57e-01 | -0.0179 |
283820 | NOMO2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.96e-28 | 7.60e-01 | 0.096 |
283820 | NOMO2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.67e-06 | 7.00e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOMO2 | SNV | Missense_Mutation | novel | c.1738N>A | p.Val580Met | p.V580M | Q5JPE7 | protein_coding | deleterious(0.01) | benign(0.306) | TCGA-A2-A0ST-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NOMO2 | SNV | Missense_Mutation | novel | c.1131N>G | p.Ile377Met | p.I377M | Q5JPE7 | protein_coding | tolerated(0.06) | possibly_damaging(0.622) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NOMO2 | SNV | Missense_Mutation | novel | c.839N>T | p.Ser280Phe | p.S280F | Q5JPE7 | protein_coding | tolerated(0.05) | benign(0.359) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NOMO2 | SNV | Missense_Mutation | novel | c.162N>G | p.Ile54Met | p.I54M | Q5JPE7 | protein_coding | deleterious(0) | benign(0.378) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
NOMO2 | SNV | Missense_Mutation | c.1258N>A | p.Pro420Thr | p.P420T | Q5JPE7 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-D8-A1Y0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide+methotrexatum+fluorouracillum | SD | |
NOMO2 | SNV | Missense_Mutation | rs758517656 | c.2065N>A | p.Asp689Asn | p.D689N | Q5JPE7 | protein_coding | tolerated(0.15) | benign(0.223) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
NOMO2 | SNV | Missense_Mutation | rs554396078 | c.967G>A | p.Val323Met | p.V323M | Q5JPE7 | protein_coding | tolerated(0.1) | benign(0.226) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NOMO2 | SNV | Missense_Mutation | rs141824052 | c.2240N>A | p.Gly747Asp | p.G747D | Q5JPE7 | protein_coding | tolerated(0.09) | possibly_damaging(0.573) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOMO2 | SNV | Missense_Mutation | novel | c.1741N>C | p.Ser581Pro | p.S581P | Q5JPE7 | protein_coding | tolerated(0.21) | benign(0.184) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
NOMO2 | SNV | Missense_Mutation | novel | c.1817N>G | p.Gln606Arg | p.Q606R | Q5JPE7 | protein_coding | tolerated(0.17) | benign(0.439) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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