Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NMT1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NMT1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NMT1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NMT1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NMT1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00486604 | Endometrium | AEH | regulation of smooth muscle cell proliferation | 43/2100 | 180/18723 | 1.09e-06 | 3.68e-05 | 43 |
GO:200125210 | Endometrium | AEH | positive regulation of chromosome organization | 25/2100 | 82/18723 | 1.95e-06 | 5.93e-05 | 25 |
GO:00486594 | Endometrium | AEH | smooth muscle cell proliferation | 43/2100 | 184/18723 | 2.04e-06 | 6.14e-05 | 43 |
GO:00330022 | Endometrium | AEH | muscle cell proliferation | 51/2100 | 248/18723 | 1.26e-05 | 2.77e-04 | 51 |
GO:00072657 | Endometrium | AEH | Ras protein signal transduction | 63/2100 | 337/18723 | 3.09e-05 | 5.66e-04 | 63 |
GO:00426925 | Endometrium | AEH | muscle cell differentiation | 68/2100 | 384/18723 | 8.88e-05 | 1.30e-03 | 68 |
GO:00330446 | Endometrium | AEH | regulation of chromosome organization | 36/2100 | 187/18723 | 8.27e-04 | 7.73e-03 | 36 |
GO:00011017 | Endometrium | AEH | response to acid chemical | 28/2100 | 135/18723 | 9.24e-04 | 8.43e-03 | 28 |
GO:00486613 | Endometrium | AEH | positive regulation of smooth muscle cell proliferation | 23/2100 | 104/18723 | 1.03e-03 | 9.15e-03 | 23 |
GO:00432005 | Endometrium | AEH | response to amino acid | 24/2100 | 116/18723 | 2.14e-03 | 1.65e-02 | 24 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:00712302 | Endometrium | AEH | cellular response to amino acid stimulus | 16/2100 | 71/18723 | 4.68e-03 | 2.99e-02 | 16 |
GO:1904705 | Endometrium | AEH | regulation of vascular associated smooth muscle cell proliferation | 19/2100 | 90/18723 | 4.69e-03 | 2.99e-02 | 19 |
GO:1990874 | Endometrium | AEH | vascular associated smooth muscle cell proliferation | 19/2100 | 91/18723 | 5.32e-03 | 3.32e-02 | 19 |
GO:1904707 | Endometrium | AEH | positive regulation of vascular associated smooth muscle cell proliferation | 12/2100 | 49/18723 | 6.75e-03 | 3.94e-02 | 12 |
GO:00712293 | Endometrium | AEH | cellular response to acid chemical | 17/2100 | 80/18723 | 6.76e-03 | 3.94e-02 | 17 |
GO:0031453 | Endometrium | AEH | positive regulation of heterochromatin assembly | 5/2100 | 12/18723 | 7.10e-03 | 4.09e-02 | 5 |
GO:0120263 | Endometrium | AEH | positive regulation of heterochromatin organization | 5/2100 | 12/18723 | 7.10e-03 | 4.09e-02 | 5 |
GO:0051148 | Endometrium | AEH | negative regulation of muscle cell differentiation | 15/2100 | 68/18723 | 7.45e-03 | 4.23e-02 | 15 |
GO:200125213 | Endometrium | EEC | positive regulation of chromosome organization | 26/2168 | 82/18723 | 9.70e-07 | 3.31e-05 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NMT1 | SNV | Missense_Mutation | | c.344N>A | p.Arg115Gln | p.R115Q | P30419 | protein_coding | tolerated(0.08) | benign(0.138) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | novel | c.763N>T | p.Arg255Cys | p.R255C | P30419 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | novel | c.177N>T | p.Lys59Asn | p.K59N | P30419 | protein_coding | tolerated(0.12) | benign(0.264) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | | c.732N>T | p.Glu244Asp | p.E244D | P30419 | protein_coding | deleterious(0.02) | benign(0.232) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NMT1 | insertion | Frame_Shift_Ins | novel | c.965_966insAGGTATTCATTGTCTGGTGACTTTATATAAGAAAGGAA | p.Thr323GlyfsTer15 | p.T323Gfs*15 | P30419 | protein_coding | | | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD |
NMT1 | insertion | Frame_Shift_Ins | novel | c.792_793insAGTT | p.Arg265SerfsTer45 | p.R265Sfs*45 | P30419 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMT1 | insertion | Frame_Shift_Ins | novel | c.793_794insCTACCATGCCAGGGGGCAGAAGGATTTGT | p.Arg265ProfsTer47 | p.R265Pfs*47 | P30419 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | novel | c.532G>C | p.Glu178Gln | p.E178Q | P30419 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
NMT1 | SNV | Missense_Mutation | novel | c.1368N>T | p.Met456Ile | p.M456I | P30419 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NMT1 | SNV | Missense_Mutation | | c.10G>A | p.Glu4Lys | p.E4K | P30419 | protein_coding | deleterious_low_confidence(0.04) | benign(0.017) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |