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Gene: MLLT4 |
Gene summary for MLLT4 |
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Gene information | Species | Human | Gene symbol | MLLT4 | Gene ID | 4301 |
Gene name | afadin, adherens junction formation factor | |
Gene Alias | AF6 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0001885 | UniProtAcc | P55196 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4301 | MLLT4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.42e-58 | 1.04e+00 | 0.294 |
4301 | MLLT4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.60e-16 | 9.63e-01 | 0.3487 |
4301 | MLLT4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.91e-54 | 1.44e+00 | 0.281 |
4301 | MLLT4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.78e-48 | 8.53e-01 | 0.3859 |
4301 | MLLT4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.50e-16 | 6.07e-01 | 0.2585 |
4301 | MLLT4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.75e-18 | 4.59e-01 | 0.3005 |
4301 | MLLT4 | P1T-E | Human | Esophagus | ESCC | 2.65e-12 | 4.95e-01 | 0.0875 |
4301 | MLLT4 | P2T-E | Human | Esophagus | ESCC | 1.59e-30 | 5.02e-01 | 0.1177 |
4301 | MLLT4 | P4T-E | Human | Esophagus | ESCC | 1.13e-25 | 4.70e-01 | 0.1323 |
4301 | MLLT4 | P5T-E | Human | Esophagus | ESCC | 3.87e-34 | 6.10e-01 | 0.1327 |
4301 | MLLT4 | P8T-E | Human | Esophagus | ESCC | 9.78e-30 | 5.54e-01 | 0.0889 |
4301 | MLLT4 | P9T-E | Human | Esophagus | ESCC | 1.08e-07 | 2.08e-01 | 0.1131 |
4301 | MLLT4 | P10T-E | Human | Esophagus | ESCC | 2.27e-21 | 3.59e-01 | 0.116 |
4301 | MLLT4 | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.93e-01 | 0.1426 |
4301 | MLLT4 | P12T-E | Human | Esophagus | ESCC | 5.17e-27 | 5.13e-01 | 0.1122 |
4301 | MLLT4 | P15T-E | Human | Esophagus | ESCC | 3.20e-25 | 4.99e-01 | 0.1149 |
4301 | MLLT4 | P16T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.64e-01 | 0.1153 |
4301 | MLLT4 | P17T-E | Human | Esophagus | ESCC | 3.47e-14 | 4.83e-01 | 0.1278 |
4301 | MLLT4 | P20T-E | Human | Esophagus | ESCC | 1.35e-11 | 2.62e-01 | 0.1124 |
4301 | MLLT4 | P21T-E | Human | Esophagus | ESCC | 3.02e-26 | 5.07e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa04670110 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa0467025 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa0467035 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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