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Gene: MIR4435-1HG |
Gene summary for MIR4435-1HG |
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Gene information | Species | Human | Gene symbol | MIR4435-1HG | Gene ID | 541471 |
Gene name | MIR4435-2 host gene | |
Gene Alias | AGD2 | |
Cytomap | 2q13 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
541471 | MIR4435-1HG | Pt13.a | Human | Liver | HCC | 1.97e-18 | 4.31e-01 | 0.021 |
541471 | MIR4435-1HG | Pt13.b | Human | Liver | HCC | 5.95e-58 | 7.65e-01 | 0.0251 |
541471 | MIR4435-1HG | Pt13.c | Human | Liver | HCC | 2.81e-04 | 3.08e-01 | 0.0076 |
541471 | MIR4435-1HG | Pt14.a | Human | Liver | HCC | 6.32e-09 | 3.64e-01 | 0.0169 |
541471 | MIR4435-1HG | Pt14.b | Human | Liver | HCC | 4.39e-19 | 5.92e-01 | 0.018 |
541471 | MIR4435-1HG | Pt14.d | Human | Liver | HCC | 4.30e-12 | 2.74e-01 | 0.0143 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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