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Gene: MARF1 |
Gene summary for MARF1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MARF1 | Gene ID | 9665 |
Gene name | meiosis regulator and mRNA stability factor 1 | |
Gene Alias | KIAA0430 | |
Cytomap | 16p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9Y4F3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9665 | MARF1 | male-WTA | Human | Thyroid | PTC | 4.60e-30 | 3.67e-01 | 0.1037 |
9665 | MARF1 | nodule-WTA | Human | Thyroid | goiters | 3.04e-04 | 2.28e-01 | 0.0534 |
9665 | MARF1 | PTC01 | Human | Thyroid | PTC | 2.71e-09 | 2.16e-01 | 0.1899 |
9665 | MARF1 | PTC03 | Human | Thyroid | PTC | 3.59e-11 | 3.25e-01 | 0.1784 |
9665 | MARF1 | PTC04 | Human | Thyroid | PTC | 5.37e-18 | 3.19e-01 | 0.1927 |
9665 | MARF1 | PTC05 | Human | Thyroid | PTC | 2.70e-19 | 5.85e-01 | 0.2065 |
9665 | MARF1 | PTC06 | Human | Thyroid | PTC | 7.37e-28 | 5.55e-01 | 0.2057 |
9665 | MARF1 | PTC07 | Human | Thyroid | PTC | 2.56e-35 | 5.22e-01 | 0.2044 |
9665 | MARF1 | ATC12 | Human | Thyroid | ATC | 4.25e-14 | 2.89e-01 | 0.34 |
9665 | MARF1 | ATC13 | Human | Thyroid | ATC | 8.75e-26 | 4.41e-01 | 0.34 |
9665 | MARF1 | ATC2 | Human | Thyroid | ATC | 9.94e-09 | 5.69e-01 | 0.34 |
9665 | MARF1 | ATC4 | Human | Thyroid | ATC | 1.34e-18 | 3.60e-01 | 0.34 |
9665 | MARF1 | ATC5 | Human | Thyroid | ATC | 5.07e-25 | 4.89e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ATC: Anaplastic thyroid cancer | |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | |
Oral cavity | LP | |
Oral cavity | EOLP | |
Oral cavity | NEOLP | |
Esophagus | HGIN |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482855 | Thyroid | PTC | organelle fission | 188/5968 | 488/18723 | 9.64e-04 | 5.77e-03 | 188 |
GO:00063026 | Thyroid | PTC | double-strand break repair | 103/5968 | 251/18723 | 1.30e-03 | 7.40e-03 | 103 |
GO:00002804 | Thyroid | PTC | nuclear division | 167/5968 | 439/18723 | 3.27e-03 | 1.60e-02 | 167 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:000630212 | Thyroid | ATC | double-strand break repair | 110/6293 | 251/18723 | 4.48e-04 | 2.65e-03 | 110 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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