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Gene: MARCHF8 |
Gene summary for MARCHF8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MARCHF8 | Gene ID | 220972 |
| Gene name | membrane associated ring-CH-type finger 8 | |
| Gene Alias | CMIR | |
| Cytomap | 10q11.21-q11.22 | |
| Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | A0A024R7U2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 220972 | MARCHF8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.83e-02 | 9.73e-02 | 0.0155 |
| 220972 | MARCHF8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.32e-13 | 3.24e-01 | -0.1808 |
| 220972 | MARCHF8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.45e-11 | 3.30e-01 | -0.0811 |
| 220972 | MARCHF8 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.17e-12 | 3.32e-01 | -0.1088 |
| 220972 | MARCHF8 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.13e-33 | 6.22e-01 | -0.1954 |
| 220972 | MARCHF8 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 3.68e-01 | -0.2602 |
| 220972 | MARCHF8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 2.12e-01 | -0.2196 |
| 220972 | MARCHF8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.26e-04 | 1.69e-01 | -0.1207 |
| 220972 | MARCHF8 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.80e-11 | 3.47e-01 | -0.1526 |
| 220972 | MARCHF8 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.05e-01 | -0.1464 |
| 220972 | MARCHF8 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.83e-12 | 2.78e-01 | -0.1001 |
| 220972 | MARCHF8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-09 | 2.62e-01 | -0.059 |
| 220972 | MARCHF8 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 1.89e-01 | -0.1706 |
| 220972 | MARCHF8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.00e-07 | 3.63e-01 | -0.2061 |
| 220972 | MARCHF8 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.04e-01 | -0.0842 |
| 220972 | MARCHF8 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.00410000000000005 |
| 220972 | MARCHF8 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.98e-03 | 1.42e-01 | 0.096 |
| 220972 | MARCHF8 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 1.83e-01 | 0.0528 |
| 220972 | MARCHF8 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-07 | 3.34e-01 | 0.0131 |
| 220972 | MARCHF8 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.21e-08 | 3.35e-01 | -0.0177 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Oral cavity | OSCC |  |
| Oral cavity | LP |  |
| Oral cavity | EOLP |  |
| Oral cavity | NEOLP |  |
| Esophagus | HGIN |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
| GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
| GO:0048002 | Colorectum | SER | antigen processing and presentation of peptide antigen | 19/2897 | 62/18723 | 1.96e-03 | 1.97e-02 | 19 |
| GO:0019882 | Colorectum | SER | antigen processing and presentation | 28/2897 | 106/18723 | 2.52e-03 | 2.34e-02 | 28 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 220972 | MARCHF8 | ENZYME | Aflunov | |||
| 220972 | MARCHF8 | ENZYME | Live attenuated influenza vaccine | |||
| 220972 | MARCHF8 | ENZYME | Focetria A(H1N1) | |||
| 220972 | MARCHF8 | ENZYME | Arepanrix | |||
| 220972 | MARCHF8 | ENZYME | GMZ-2 | 22166048 | ||
| 220972 | MARCHF8 | ENZYME | Grippol TC | |||
| 220972 | MARCHF8 | ENZYME | H5N1 influenza vaccine | |||
| 220972 | MARCHF8 | ENZYME | H1N1 influenza vaccine | |||
| 220972 | MARCHF8 | ENZYME | HBV vaccine | |||
| 220972 | MARCHF8 | ENZYME | H1N1 pandemic influenza A vaccine |
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