GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332020 | Oral cavity | OSCC | regulation of protein modification by small protein conjugation or removal | 165/7305 | 242/18723 | 2.52e-20 | 3.99e-18 | 165 |
GO:003139620 | Oral cavity | OSCC | regulation of protein ubiquitination | 143/7305 | 210/18723 | 1.01e-17 | 9.80e-16 | 143 |
GO:005134820 | Oral cavity | OSCC | negative regulation of transferase activity | 165/7305 | 268/18723 | 5.02e-14 | 2.74e-12 | 165 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:190290520 | Oral cavity | OSCC | positive regulation of supramolecular fiber organization | 131/7305 | 209/18723 | 3.18e-12 | 1.27e-10 | 131 |
GO:000155816 | Oral cavity | OSCC | regulation of cell growth | 228/7305 | 414/18723 | 1.74e-11 | 6.09e-10 | 228 |
GO:190290320 | Oral cavity | OSCC | regulation of supramolecular fiber organization | 211/7305 | 383/18723 | 9.45e-11 | 2.88e-09 | 211 |
GO:003139720 | Oral cavity | OSCC | negative regulation of protein ubiquitination | 61/7305 | 83/18723 | 1.78e-10 | 5.17e-09 | 61 |
GO:005149518 | Oral cavity | OSCC | positive regulation of cytoskeleton organization | 135/7305 | 226/18723 | 1.98e-10 | 5.66e-09 | 135 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:190332120 | Oral cavity | OSCC | negative regulation of protein modification by small protein conjugation or removal | 65/7305 | 95/18723 | 5.88e-09 | 1.26e-07 | 65 |
GO:000701520 | Oral cavity | OSCC | actin filament organization | 230/7305 | 442/18723 | 1.37e-08 | 2.77e-07 | 230 |
GO:003297020 | Oral cavity | OSCC | regulation of actin filament-based process | 209/7305 | 397/18723 | 1.89e-08 | 3.72e-07 | 209 |
GO:003253519 | Oral cavity | OSCC | regulation of cellular component size | 201/7305 | 383/18723 | 4.80e-08 | 8.88e-07 | 201 |
GO:003295620 | Oral cavity | OSCC | regulation of actin cytoskeleton organization | 189/7305 | 358/18723 | 6.81e-08 | 1.21e-06 | 189 |
GO:011005320 | Oral cavity | OSCC | regulation of actin filament organization | 150/7305 | 278/18723 | 2.68e-07 | 4.15e-06 | 150 |
GO:00107209 | Oral cavity | OSCC | positive regulation of cell development | 159/7305 | 298/18723 | 3.06e-07 | 4.66e-06 | 159 |
GO:005143810 | Oral cavity | OSCC | regulation of ubiquitin-protein transferase activity | 37/7305 | 53/18723 | 5.37e-06 | 6.04e-05 | 37 |
GO:00507696 | Oral cavity | OSCC | positive regulation of neurogenesis | 120/7305 | 225/18723 | 8.45e-06 | 9.02e-05 | 120 |
GO:00303079 | Oral cavity | OSCC | positive regulation of cell growth | 92/7305 | 166/18723 | 1.27e-05 | 1.29e-04 | 92 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIMK1 | SNV | Missense_Mutation | | c.1567N>A | p.Gly523Ser | p.G523S | P53667 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | novel | c.139N>T | p.Ala47Ser | p.A47S | P53667 | protein_coding | tolerated(0.87) | benign(0.007) | TCGA-PE-A5DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | CR |
LIMK1 | insertion | Frame_Shift_Ins | novel | c.544_545insACCAGGAAGCTTCACTGAGCTTCAGCAGCCAGAGTTT | p.Ile182AsnfsTer14 | p.I182Nfs*14 | P53667 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | insertion | Frame_Shift_Ins | novel | c.1712_1713insC | p.Asn574LysfsTer71 | p.N574Kfs*71 | P53667 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | | c.358G>A | p.Asp120Asn | p.D120N | P53667 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
LIMK1 | SNV | Missense_Mutation | | c.1557N>C | p.Glu519Asp | p.E519D | P53667 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LIMK1 | SNV | Missense_Mutation | | c.646N>A | p.Ser216Thr | p.S216T | P53667 | protein_coding | tolerated(0.11) | benign(0.117) | TCGA-EA-A556-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | rs782256257 | c.985C>T | p.Arg329Trp | p.R329W | P53667 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-IR-A3LC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | Complete Response |
LIMK1 | SNV | Missense_Mutation | novel | c.1563N>G | p.Ile521Met | p.I521M | P53667 | protein_coding | tolerated(0.71) | benign(0.323) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
LIMK1 | SNV | Missense_Mutation | novel | c.1864N>C | p.Glu622Gln | p.E622Q | P53667 | protein_coding | deleterious(0.04) | possibly_damaging(0.65) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | PAZOPANIB | PAZOPANIB | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | GO-6976 | GO-6976 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | CENISERTIB | CENISERTIB | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | TAE-684 | TAE-684 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | BMS-345541 | BMS-345541 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | TCMDC-125758 | CHEMBL546797 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565797 | | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | SB-220025 | SB-220025 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | RG-1530 | RG-1530 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 363894217 | VORUCICLIB | |