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Gene: KCNK7 |
Gene summary for KCNK7 |
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Gene information | Species | Human | Gene symbol | KCNK7 | Gene ID | 10089 |
Gene name | potassium two pore domain channel subfamily K member 7 | |
Gene Alias | K2p7.1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R5F5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10089 | KCNK7 | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.89e-01 | 0.1323 |
10089 | KCNK7 | P12T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.41e-01 | 0.1122 |
10089 | KCNK7 | P15T-E | Human | Esophagus | ESCC | 5.37e-05 | 1.44e-01 | 0.1149 |
10089 | KCNK7 | P27T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.62e-01 | 0.1055 |
10089 | KCNK7 | P28T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.94e-01 | 0.1149 |
10089 | KCNK7 | P31T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.09e-01 | 0.1251 |
10089 | KCNK7 | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 1.24e-01 | 0.1175 |
10089 | KCNK7 | P49T-E | Human | Esophagus | ESCC | 4.64e-06 | 5.70e-01 | 0.1768 |
10089 | KCNK7 | P74T-E | Human | Esophagus | ESCC | 8.28e-10 | 3.38e-01 | 0.1479 |
10089 | KCNK7 | P83T-E | Human | Esophagus | ESCC | 8.77e-03 | 1.24e-01 | 0.1738 |
10089 | KCNK7 | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 6.50e-01 | 0.1828 |
10089 | KCNK7 | P130T-E | Human | Esophagus | ESCC | 1.62e-13 | 3.04e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNK7 | SNV | Missense_Mutation | c.807N>G | p.Phe269Leu | p.F269L | Q9Y2U2 | protein_coding | deleterious(0) | possibly_damaging(0.626) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
KCNK7 | SNV | Missense_Mutation | novel | c.698N>C | p.Leu233Pro | p.L233P | Q9Y2U2 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNK7 | SNV | Missense_Mutation | novel | c.590N>A | p.Cys197Tyr | p.C197Y | Q9Y2U2 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KCNK7 | SNV | Missense_Mutation | rs779924861 | c.664N>T | p.Arg222Cys | p.R222C | Q9Y2U2 | protein_coding | deleterious(0.01) | possibly_damaging(0.536) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KCNK7 | SNV | Missense_Mutation | rs750933271 | c.96N>T | p.Glu32Asp | p.E32D | Q9Y2U2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KCNK7 | SNV | Missense_Mutation | c.17N>T | p.Pro6Leu | p.P6L | Q9Y2U2 | protein_coding | deleterious(0) | benign(0.185) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
KCNK7 | SNV | Missense_Mutation | c.286C>A | p.Leu96Met | p.L96M | Q9Y2U2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KCNK7 | SNV | Missense_Mutation | c.344C>T | p.Ser115Leu | p.S115L | Q9Y2U2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCNK7 | SNV | Missense_Mutation | rs779624062 | c.422G>A | p.Arg141His | p.R141H | Q9Y2U2 | protein_coding | tolerated(0.09) | benign(0.052) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KCNK7 | SNV | Missense_Mutation | rs749274421 | c.661G>A | p.Gly221Ser | p.G221S | Q9Y2U2 | protein_coding | tolerated(0.12) | benign(0.227) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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