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Gene: HEPACAM2 |
Gene summary for HEPACAM2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | HEPACAM2 | Gene ID | 253012 |
Gene name | HEPACAM family member 2 | |
Gene Alias | MIKI | |
Cytomap | 7q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A8MVW5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253012 | HEPACAM2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.14e-17 | 1.25e+00 | -0.1088 |
253012 | HEPACAM2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.31e-03 | 4.32e-01 | -0.1207 |
253012 | HEPACAM2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.09e-06 | 3.52e-01 | -0.1464 |
253012 | HEPACAM2 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.32e-06 | 3.75e-01 | -0.1001 |
253012 | HEPACAM2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.69e-04 | 6.45e-01 | 0.3487 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | |
Oral cavity | LP | |
Oral cavity | EOLP | |
Oral cavity | NEOLP | |
Esophagus | HGIN |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HEPACAM2 | SNV | Missense_Mutation | novel | c.814N>C | p.Asp272His | p.D272H | A8MVW5 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HEPACAM2 | SNV | Missense_Mutation | c.676N>G | p.Thr226Ala | p.T226A | A8MVW5 | protein_coding | tolerated(0.06) | possibly_damaging(0.672) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HEPACAM2 | SNV | Missense_Mutation | c.54N>C | p.Gln18His | p.Q18H | A8MVW5 | protein_coding | tolerated_low_confidence(0.17) | benign(0.191) | TCGA-C8-A12V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HEPACAM2 | SNV | Missense_Mutation | c.418N>A | p.Glu140Lys | p.E140K | A8MVW5 | protein_coding | deleterious(0.04) | possibly_damaging(0.73) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
HEPACAM2 | insertion | In_Frame_Ins | novel | c.818_819insTTTTCTTTTCTACCT | p.Lys273delinsAsnPheLeuPheTyrLeu | p.K273delinsNFLFYL | A8MVW5 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HEPACAM2 | insertion | Frame_Shift_Ins | novel | c.1110_1111insCCTATTTATCCAGTTAAGCTCAAGGCTGTCACTAAGAAGTC | p.Ser371ProfsTer19 | p.S371Pfs*19 | A8MVW5 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HEPACAM2 | deletion | Frame_Shift_Del | novel | c.1267delN | p.Ser423GlnfsTer77 | p.S423Qfs*77 | A8MVW5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
HEPACAM2 | SNV | Missense_Mutation | novel | c.1004N>G | p.Asp335Gly | p.D335G | A8MVW5 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HEPACAM2 | SNV | Missense_Mutation | c.533C>A | p.Pro178His | p.P178H | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HEPACAM2 | SNV | Missense_Mutation | c.956G>T | p.Gly319Val | p.G319V | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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